Xiaoyu Xu1,2, Xiaolin Wang1, SriniVas R Sadda1, Yuhua Zhang3. 1. Doheny Eye Institute, Department of Ophthalmology, University of California - Los Angeles, 1355 San Pablo Street, Los Angeles, CA, 90033, USA. 2. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China. 3. Doheny Eye Institute, Department of Ophthalmology, University of California - Los Angeles, 1355 San Pablo Street, Los Angeles, CA, 90033, USA. yzhang@doheny.org.
Abstract
PURPOSE: To examine the structure of photoreceptors surrounding two subtypes of subretinal drusenoid deposits (SDD), namely, dot and ribbon SDD, using multimodal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral-domain optical coherence tomography (SD-OCT). METHODS: Twenty-six eyes of 13 patients with age-related macular degeneration (AMD) and SDD and 16 eyes of 8 subjects in normal chorioretinal health were studied. SDD presence, stage, and subtype were determined using color fundus photographs, infrared reflectance, autofluorescence imaging, and SD-OCT. SDD and surrounding photoreceptors were imaged using AOSLO. The structure of cone photoreceptors and SDD was examined at the baseline and at 2-year follow-up studies in 6 patients. RESULTS: Dot SDD were identified in 18 eyes of 9 patients and coexisting dot and ribbon SDD were observed in 8 eyes of 4 patients. While a characteristic photoreceptor mosaic was clearly revealed by AOSLO in the area unaffected by lesions in those eyes with dot-only SDD, in unaffected areas adjacent to retinal regions with predominantly ribbon SDD, photoreceptors could no longer be visualized. CONCLUSION: The invisibility of the photoreceptor mosaic in unaffected areas adjacent to retinal regions with predominantly ribbon SDD suggests degeneration in the outer segment and the interdigitation zone, which impairs the waveguiding ability of the photoreceptors. Our study implies possible differentiation of disease outcome and functional impact in different types of SDD.
PURPOSE: To examine the structure of photoreceptors surrounding two subtypes of subretinal drusenoid deposits (SDD), namely, dot and ribbon SDD, using multimodal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral-domain optical coherence tomography (SD-OCT). METHODS: Twenty-six eyes of 13 patients with age-related macular degeneration (AMD) and SDD and 16 eyes of 8 subjects in normal chorioretinal health were studied. SDD presence, stage, and subtype were determined using color fundus photographs, infrared reflectance, autofluorescence imaging, and SD-OCT. SDD and surrounding photoreceptors were imaged using AOSLO. The structure of cone photoreceptors and SDD was examined at the baseline and at 2-year follow-up studies in 6 patients. RESULTS: Dot SDD were identified in 18 eyes of 9 patients and coexisting dot and ribbon SDD were observed in 8 eyes of 4 patients. While a characteristic photoreceptor mosaic was clearly revealed by AOSLO in the area unaffected by lesions in those eyes with dot-only SDD, in unaffected areas adjacent to retinal regions with predominantly ribbon SDD, photoreceptors could no longer be visualized. CONCLUSION: The invisibility of the photoreceptor mosaic in unaffected areas adjacent to retinal regions with predominantly ribbon SDD suggests degeneration in the outer segment and the interdigitation zone, which impairs the waveguiding ability of the photoreceptors. Our study implies possible differentiation of disease outcome and functional impact in different types of SDD.
Authors: Yuhua Zhang; Xiaolin Wang; Pooja Godara; Tianjiao Zhang; Mark E Clark; C Douglas Witherspoon; Richard F Spaide; Cynthia Owsley; Christine A Curcio Journal: Retina Date: 2018-01 Impact factor: 4.256
Authors: Yuhua Zhang; Xiaolin Wang; Srinivas R Sadda; Mark E Clark; C Douglas Witherspoon; Richard F Spaide; Cynthia Owsley; Christine A Curcio Journal: Ophthalmol Retina Date: 2019-10-31
Authors: Ethan A Rossi; Nathaniel Norberg; Chiara Eandi; Celine Chaumette; Saloni Kapoor; Laura Le; Valerie C Snyder; Joseph N Martel; Josselin Gautier; Kiyoko Gocho; Kunal K Dansingani; Jay Chhablani; Angelo Arleo; Sarah Mrejen; José-Alain Sahel; Kate Grieve; Michel Paques Journal: Transl Vis Sci Technol Date: 2021-12-01 Impact factor: 3.048