AIMS: To report observations relating to the clinical recognition and possible basis of reticular pseudodrusen (RPD). METHODS: This retrospective study reports the evolution of RPD in 166 patients who had follow-up of over 1 year using multiple imaging techniques. Mean age when first seen was 73.3 years and the mean period of observation was 4.9 years (range 1-18 years). Associated macular changes were recorded. RESULTS: RPD were first identified in the upper fundus as a reticular network, which then became less obvious, developing a diffuse yellowish appearance. RPD also faded around choroidal neovascularisation (CNV). RPD therefore could be transient but the pattern often remained visible outside the macula or nasal to the discs. Manifestations of age-related macular degeneration (AMD) were present in nearly all eyes and there was a particularly high association with CNV (52.1%). In one clinicopathological case abnormal material was found in the subretinal space. CONCLUSIONS: The prevalence of RPD may be underestimated because their recognition depends upon the imaging method used, the area of fundus examined and the confusion with typical drusen. The pathology of one eye suggests that RPD may correspond to material in the subretinal space.
AIMS: To report observations relating to the clinical recognition and possible basis of reticular pseudodrusen (RPD). METHODS: This retrospective study reports the evolution of RPD in 166 patients who had follow-up of over 1 year using multiple imaging techniques. Mean age when first seen was 73.3 years and the mean period of observation was 4.9 years (range 1-18 years). Associated macular changes were recorded. RESULTS: RPD were first identified in the upper fundus as a reticular network, which then became less obvious, developing a diffuse yellowish appearance. RPD also faded around choroidal neovascularisation (CNV). RPD therefore could be transient but the pattern often remained visible outside the macula or nasal to the discs. Manifestations of age-related macular degeneration (AMD) were present in nearly all eyes and there was a particularly high association with CNV (52.1%). In one clinicopathological case abnormal material was found in the subretinal space. CONCLUSIONS: The prevalence of RPD may be underestimated because their recognition depends upon the imaging method used, the area of fundus examined and the confusion with typical drusen. The pathology of one eye suggests that RPD may correspond to material in the subretinal space.
Authors: Patrick A Kaszubski; Tal Ben Ami; Céline Saade; Camellia Nabati; Vivek Kumar; Ana Rita Santos; Rufino Silva; Maria Luz Cachulo; José G Cunha-Vaz; R Theodore Smith Journal: Int Ophthalmol Date: 2017-03-07 Impact factor: 2.031
Authors: Aakriti Garg; Maris Oll; Suzanne Yzer; Stanley Chang; Gaetano R Barile; John C Merriam; Stephen H Tsang; Srilaxmi Bearelly Journal: Invest Ophthalmol Vis Sci Date: 2013-10-29 Impact factor: 4.799
Authors: Yuhua Zhang; Xiaolin Wang; Pooja Godara; Tianjiao Zhang; Mark E Clark; C Douglas Witherspoon; Richard F Spaide; Cynthia Owsley; Christine A Curcio Journal: Retina Date: 2018-01 Impact factor: 4.256