Literature DB >> 3245835

Aging influence on delta-6-desaturase activity and fatty acid composition of rat liver microsomes.

A Bordoni1, P L Biagi, E Turchetto, S Hrelia.   

Abstract

The activity of delta-6-desaturase (D6D) in liver microsomes and fatty acid composition of microsomal lipids of rats of different ages were studied. The D6D activity was similar in suckling rats and in weaning rats. However, the enzyme showed a significantly decreased activity in oldest animals, and a linear correlation was found between the D6D activity and the animal age. The fatty acid composition data on total lipids of liver microsomes were consistent with the age-dependent changes in fatty acid desaturase activity. The major changes occurred in the linoleate and arachidonate fractions; the 20:4/18:2 ratio in liver microsomes decreased together with D6D activity during aging. The loss of D6D activity may be a key factor in aging through altering lipid membrane composition.

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Year:  1988        PMID： 3245835

Source DB:  PubMed          Journal:  Biochem Int        ISSN： 0158-5231


  13 in total

1.  Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver.

Authors:  Fei Gao; Ameer Y Taha; Kaizong Ma; Lisa Chang; Dale Kiesewetter; Stanley I Rapoport
Journal:  Age (Dordr)       Date:  2012-03-03

2.  Diabetes-induced and age-related changes in fatty acid proportions of plasma lipids in rats.

Authors:  S Nishida; T Kanno; S Nakagawa
Journal:  Lipids       Date:  1998-03       Impact factor: 1.880

3.  Inhibition of delta-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function.

Authors:  Christopher M Mulligan; Catherine H Le; Anthony B deMooy; Christopher B Nelson; Adam J Chicco
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-01-13       Impact factor: 6.053

4.  Effects of age and dietary essential fatty acids on desaturase activities and on fatty acid composition of liver microsomal phospholipids of adult rats.

Authors:  L Ulmann; J P Blond; C Maniongui; J P Poisson; G Durand; J Bézard; G Pascal
Journal:  Lipids       Date:  1991-02       Impact factor: 1.880

5.  Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder.

Authors:  Wei Jiang; Harry Oken; Mona Fiuzat; Linda K Shaw; Carolyn Martsberger; Maragatha Kuchibhatla; Rima Kaddurah-Daouk; David C Steffens; Rebecca Baillie; Michael Cuffe; Ranga Krishnan; Christopher O'Connor
Journal:  J Cardiovasc Transl Res       Date:  2011-11-01       Impact factor: 4.132

6.  Age-related changes in linoleic acid bioconversion by isolated hepatocytes from spontaneously hypertensive and normotensive rats.

Authors:  M Narce; P Asdrubal; M C Delachambre; E Véricel; M Lagarde; J P Poisson
Journal:  Mol Cell Biochem       Date:  1994-12-07       Impact factor: 3.396

7.  Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes.

Authors:  C Maniongui; J P Blond; L Ulmann; G Durand; J P Poisson; J Bézard
Journal:  Lipids       Date:  1993-04       Impact factor: 1.880

8.  Effect of age and alpha-linolenic acid deficiency on delta 6 desaturase activity and liver lipids in rats.

Authors:  T K Dinh; J M Bourre; G Durand
Journal:  Lipids       Date:  1993-06       Impact factor: 1.880

9.  The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity.

Authors:  Robert K McNamara; Yanhong Liu; Ronald Jandacek; Therese Rider; Patrick Tso
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2008-05-21       Impact factor: 4.006

10.  Influence of spontaneous hypertension on n-3 delta-6-desaturase activity and fatty acid composition of rat hepatocytes.

Authors:  M Narce; P Asdrubal; M C Delachambre; J Gresti; J P Poisson
Journal:  Mol Cell Biochem       Date:  1995-11-08       Impact factor: 3.396
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