| Literature DB >> 32412865 |
Peter De Haan1, Ferdy R Van Diemen1, Miguel G Toscano2.
Abstract
Viruses have evolved to efficiently express their genes in host cells, which makes them ideally suited as gene delivery vectors for gene and immunotherapies. Replication competent (RC) viral vectors encoding foreign or self-proteins induce strong T-cell responses that can be used for the development of effective cancer treatments. Replication-defective (RD) viral vectors encoding self-proteins are non-immunogenic when introduced in a host naïve for the cognate virus. RD viral vectors can be used to develop gene replacement therapies for genetic disorders and tolerization therapies for autoimmune diseases and allergies. Degenerative/inflammatory diseases are associated with chronic inflammation and immune responses that damage the tissues involved. These diseases therefore strongly resemble autoimmune diseases. This review deals with the use of RC and RD viral vectors for unraveling the pathogenesis of immune-related diseases and their application to the development of the next generation prophylactics and therapeutics for todays' major diseases.Entities:
Keywords: Immune system; adeno-associated virus; alphavirus; autoimmune disease; cancer; gene therapy; immune tolerance; immunotherapy; lentivirus; self-antigen; sv40; tolerization; vaccine; viral vector
Year: 2020 PMID： 32412865 PMCID： PMC7872028 DOI： 10.1080/21645515.2020.1757989
Source DB: PubMed Journal: Hum Vaccin Immunother ISSN： 2164-5515 Impact factor: 3.452