Literature DB >> 11951031

Decoding the patterns of self and nonself by the innate immune system.

Ruslan Medzhitov1, Charles A Janeway.   

Abstract

The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and abnormal self. These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals.

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Year:  2002        PMID: 11951031     DOI: 10.1126/science.1068883

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  490 in total

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