Somayye Arjeh1, Fatemeh Darsareh2, Zhila Abedi Asl1, Maryam Azizi Kutenaei3. 1. Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. 2. Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. 3. Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Electronic address: Maryamazizikut86@gmail.com.
Abstract
BACKGROUND: and purpose: Uterine fibroids are common tumors of the female reproductive system. Symptomatic uterine fibroids require surgical or medical therapy depending on the severity of the symptoms. This study was conducted to investigate the effect of vitamin D on uterine fibroids. MATERIALS AND METHODS: A randomized clinical trial was conducted from June to November 2018. Eligible women were randomly assigned to receive vitamin D or a placebo for 12 weeks. The change in the volume of fibroids was considered to be the main variable in the efficacy evaluation. RESULTS: No statistically significant decrease in the volume of fibroids was observed in the experimental group [mean difference (MD): -0.71, 95% confidence interval (CI): -0.1 to 1.53, P = 0.085], and a significant increase was observed in the size of fibroids in the control group (MD: 2.53, 95% CI: 1.9 to 4.05, p = 0.001). CONCLUSION:Vitamin D consumption might inhibit growth of uterine fibroids; however, the long-term effects remain unclear.
RCT Entities:
BACKGROUND: and purpose: Uterine fibroids are common tumors of the female reproductive system. Symptomatic uterine fibroids require surgical or medical therapy depending on the severity of the symptoms. This study was conducted to investigate the effect of vitamin D on uterine fibroids. MATERIALS AND METHODS: A randomized clinical trial was conducted from June to November 2018. Eligible women were randomly assigned to receive vitamin D or a placebo for 12 weeks. The change in the volume of fibroids was considered to be the main variable in the efficacy evaluation. RESULTS: No statistically significant decrease in the volume of fibroids was observed in the experimental group [mean difference (MD): -0.71, 95% confidence interval (CI): -0.1 to 1.53, P = 0.085], and a significant increase was observed in the size of fibroids in the control group (MD: 2.53, 95% CI: 1.9 to 4.05, p = 0.001). CONCLUSION:Vitamin D consumption might inhibit growth of uterine fibroids; however, the long-term effects remain unclear.
Authors: Qiwei Yang; Michal Ciebiera; Maria Victoria Bariani; Mohamed Ali; Hoda Elkafas; Thomas G Boyer; Ayman Al-Hendy Journal: Endocr Rev Date: 2022-07-13 Impact factor: 25.261