Literature DB >> 32374820

Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study.

Eirini Marouli1,2, Aleksander Kus3,4,5, Fabiola Del Greco M6, Layal Chaker3,4, Robin Peeters3,4, Alexander Teumer7,8, Panos Deloukas1,2,9, Marco Medici3,4,10.   

Abstract

CONTEXT: Observational studies suggest that variations in normal range thyroid function are associated with cardiovascular diseases. However, it remains to be determined whether these associations are causal or not.
OBJECTIVE: To test whether genetically determined variation in normal range thyroid function is causally associated with the risk of stroke and coronary artery disease (CAD) and investigate via which pathways these relations may be mediated. DESIGN, SETTING, AND PARTICIPANTS: Mendelian randomization analyses for stroke and CAD using genetic instruments associated with normal range thyrotropin (TSH) and free thyroxine levels or Hashimoto's thyroiditis and Graves' disease. The potential mediating role of known stroke and CAD risk factors was examined. Publicly available summary statistics data were used. MAIN OUTCOME MEASURES: Stroke or CAD risk per genetically predicted increase in TSH or FT4 levels.
RESULTS: A 1 standard deviation increase in TSH was associated with a 5% decrease in the risk of stroke (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.91-0.99; P = 0.008). Multivariable MR analyses indicated that this effect is mainly mediated via atrial fibrillation. MR analyses did not show a causal association between normal range thyroid function and CAD. Secondary analyses showed a causal relationship between Hashimoto's thyroiditis and a 7% increased risk of CAD (OR, 1.07; 95% CI, 1.01-1.13; P = 0.026), which was mainly mediated via body mass index.
CONCLUSION: These results provide important new insights into the causal relationships and mediating pathways between thyroid function, stroke, and CAD. We identify variation in normal range thyroid function and Hashimoto's thyroiditis as risk factors for stroke and CAD, respectively. © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Mendelian randomization; TSH; coronary artery disease; mediation; stroke; thyroid function

Mesh：

Substances：

Year:  2020        PMID： 32374820      PMCID： PMC7316221          DOI： 10.1210/clinem/dgaa239

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  38 in total

1.  Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins.

Authors:  Pia Skov Hansen; Thomas Heiberg Brix; Thorkild I A Sørensen; Kirsten Ohm Kyvik; Laszlo Hegedüs
Journal:  J Clin Endocrinol Metab       Date:  2004-03       Impact factor: 5.958

2.  Calculating statistical power in Mendelian randomization studies.

Authors:  Marie-Jo A Brion; Konstantin Shakhbazov; Peter M Visscher
Journal:  Int J Epidemiol       Date:  2013-10       Impact factor: 7.196

3.  Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study.

Authors:  Arjola Bano; Layal Chaker; Francesco U S Mattace-Raso; Aad van der Lugt; M Arfan Ikram; Oscar H Franco; Robin P Peeters; Maryam Kavousi
Journal:  Circ Res       Date:  2017-10-31       Impact factor: 17.367

4.  Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.

Authors:  P A Wolf; R D Abbott; W B Kannel
Journal:  Stroke       Date:  1991-08       Impact factor: 7.914

Review 5.  Subclinical hyperthyroidism and the risk of coronary heart disease and mortality.

Authors:  Tinh-Hai Collet; Jacobijn Gussekloo; Douglas C Bauer; Wendy P J den Elzen; Anne R Cappola; Philippe Balmer; Giorgio Iervasi; Bjørn O Åsvold; José A Sgarbi; Henry Völzke; Bariş Gencer; Rui M B Maciel; Sabrina Molinaro; Alexandra Bremner; Robert N Luben; Patrick Maisonneuve; Jacques Cornuz; Anne B Newman; Kay-Tee Khaw; Rudi G J Westendorp; Jayne A Franklyn; Eric Vittinghoff; John P Walsh; Nicolas Rodondi
Journal:  Arch Intern Med       Date:  2012-05-28

6.  Mendelian randomization analysis with multiple genetic variants using summarized data.

Authors:  Stephen Burgess; Adam Butterworth; Simon G Thompson
Journal:  Genet Epidemiol       Date:  2013-09-20       Impact factor: 2.135

7.  Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015.

Authors:  Gregory A Roth; Catherine Johnson; Amanuel Abajobir; Foad Abd-Allah; Semaw Ferede Abera; Gebre Abyu; Muktar Ahmed; Baran Aksut; Tahiya Alam; Khurshid Alam; François Alla; Nelson Alvis-Guzman; Stephen Amrock; Hossein Ansari; Johan Ärnlöv; Hamid Asayesh; Tesfay Mehari Atey; Leticia Avila-Burgos; Ashish Awasthi; Amitava Banerjee; Aleksandra Barac; Till Bärnighausen; Lars Barregard; Neeraj Bedi; Ezra Belay Ketema; Derrick Bennett; Gebremedhin Berhe; Zulfiqar Bhutta; Shimelash Bitew; Jonathan Carapetis; Juan Jesus Carrero; Deborah Carvalho Malta; Carlos Andres Castañeda-Orjuela; Jacqueline Castillo-Rivas; Ferrán Catalá-López; Jee-Young Choi; Hanne Christensen; Massimo Cirillo; Leslie Cooper; Michael Criqui; David Cundiff; Albertino Damasceno; Lalit Dandona; Rakhi Dandona; Kairat Davletov; Samath Dharmaratne; Prabhakaran Dorairaj; Manisha Dubey; Rebecca Ehrenkranz; Maysaa El Sayed Zaki; Emerito Jose A Faraon; Alireza Esteghamati; Talha Farid; Maryam Farvid; Valery Feigin; Eric L Ding; Gerry Fowkes; Tsegaye Gebrehiwot; Richard Gillum; Audra Gold; Philimon Gona; Rajeev Gupta; Tesfa Dejenie Habtewold; Nima Hafezi-Nejad; Tesfaye Hailu; Gessessew Bugssa Hailu; Graeme Hankey; Hamid Yimam Hassen; Kalkidan Hassen Abate; Rasmus Havmoeller; Simon I Hay; Masako Horino; Peter J Hotez; Kathryn Jacobsen; Spencer James; Mehdi Javanbakht; Panniyammakal Jeemon; Denny John; Jost Jonas; Yogeshwar Kalkonde; Chante Karimkhani; Amir Kasaeian; Yousef Khader; Abdur Khan; Young-Ho Khang; Sahil Khera; Abdullah T Khoja; Jagdish Khubchandani; Daniel Kim; Dhaval Kolte; Soewarta Kosen; Kristopher J Krohn; G Anil Kumar; Gene F Kwan; Dharmesh Kumar Lal; Anders Larsson; Shai Linn; Alan Lopez; Paulo A Lotufo; Hassan Magdy Abd El Razek; Reza Malekzadeh; Mohsen Mazidi; Toni Meier; Kidanu Gebremariam Meles; George Mensah; Atte Meretoja; Haftay Mezgebe; Ted Miller; Erkin Mirrakhimov; Shafiu Mohammed; Andrew E Moran; Kamarul Imran Musa; Jagat Narula; Bruce Neal; Frida Ngalesoni; Grant Nguyen; Carla Makhlouf Obermeyer; Mayowa Owolabi; George Patton; João Pedro; Dima Qato; Mostafa Qorbani; Kazem Rahimi; Rajesh Kumar Rai; Salman Rawaf; Antônio Ribeiro; Saeid Safiri; Joshua A Salomon; Itamar Santos; Milena Santric Milicevic; Benn Sartorius; Aletta Schutte; Sadaf Sepanlou; Masood Ali Shaikh; Min-Jeong Shin; Mehdi Shishehbor; Hirbo Shore; Diego Augusto Santos Silva; Eugene Sobngwi; Saverio Stranges; Soumya Swaminathan; Rafael Tabarés-Seisdedos; Niguse Tadele Atnafu; Fisaha Tesfay; J S Thakur; Amanda Thrift; Roman Topor-Madry; Thomas Truelsen; Stefanos Tyrovolas; Kingsley Nnanna Ukwaja; Olalekan Uthman; Tommi Vasankari; Vasiliy Vlassov; Stein Emil Vollset; Tolassa Wakayo; David Watkins; Robert Weintraub; Andrea Werdecker; Ronny Westerman; Charles Shey Wiysonge; Charles Wolfe; Abdulhalik Workicho; Gelin Xu; Yuichiro Yano; Paul Yip; Naohiro Yonemoto; Mustafa Younis; Chuanhua Yu; Theo Vos; Mohsen Naghavi; Christopher Murray
Journal:  J Am Coll Cardiol       Date:  2017-05-17       Impact factor: 24.094

8.  A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

Authors:  Eleonora Porcu; Marco Medici; Giorgio Pistis; Claudia B Volpato; Scott G Wilson; Anne R Cappola; Steffan D Bos; Joris Deelen; Martin den Heijer; Rachel M Freathy; Jari Lahti; Chunyu Liu; Lorna M Lopez; Ilja M Nolte; Jeffrey R O'Connell; Toshiko Tanaka; Stella Trompet; Alice Arnold; Stefania Bandinelli; Marian Beekman; Stefan Böhringer; Suzanne J Brown; Brendan M Buckley; Clara Camaschella; Anton J M de Craen; Gail Davies; Marieke C H de Visser; Ian Ford; Tom Forsen; Timothy M Frayling; Laura Fugazzola; Martin Gögele; Andrew T Hattersley; Ad R Hermus; Albert Hofman; Jeanine J Houwing-Duistermaat; Richard A Jensen; Eero Kajantie; Margreet Kloppenburg; Ee M Lim; Corrado Masciullo; Stefano Mariotti; Cosetta Minelli; Braxton D Mitchell; Ramaiah Nagaraja; Romana T Netea-Maier; Aarno Palotie; Luca Persani; Maria G Piras; Bruce M Psaty; Katri Räikkönen; J Brent Richards; Fernando Rivadeneira; Cinzia Sala; Mona M Sabra; Naveed Sattar; Beverley M Shields; Nicole Soranzo; John M Starr; David J Stott; Fred C G J Sweep; Gianluca Usala; Melanie M van der Klauw; Diana van Heemst; Alies van Mullem; Sita H Vermeulen; W Edward Visser; John P Walsh; Rudi G J Westendorp; Elisabeth Widen; Guangju Zhai; Francesco Cucca; Ian J Deary; Johan G Eriksson; Luigi Ferrucci; Caroline S Fox; J Wouter Jukema; Lambertus A Kiemeney; Peter P Pramstaller; David Schlessinger; Alan R Shuldiner; Eline P Slagboom; André G Uitterlinden; Bijay Vaidya; Theo J Visser; Bruce H R Wolffenbuttel; Ingrid Meulenbelt; Jerome I Rotter; Tim D Spector; Andrew A Hicks; Daniela Toniolo; Serena Sanna; Robin P Peeters; Silvia Naitza
Journal:  PLoS Genet       Date:  2013-02-07       Impact factor: 5.917

9.  Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:  Evangelos Evangelou; Helen R Warren; David Mosen-Ansorena; Borbala Mifsud; Raha Pazoki; He Gao; Georgios Ntritsos; Niki Dimou; Claudia P Cabrera; Ibrahim Karaman; Fu Liang Ng; Marina Evangelou; Katarzyna Witkowska; Evan Tzanis; Jacklyn N Hellwege; Ayush Giri; Digna R Velez Edwards; Yan V Sun; Kelly Cho; J Michael Gaziano; Peter W F Wilson; Philip S Tsao; Csaba P Kovesdy; Tonu Esko; Reedik Mägi; Lili Milani; Peter Almgren; Thibaud Boutin; Stéphanie Debette; Jun Ding; Franco Giulianini; Elizabeth G Holliday; Anne U Jackson; Ruifang Li-Gao; Wei-Yu Lin; Jian'an Luan; Massimo Mangino; Christopher Oldmeadow; Bram Peter Prins; Yong Qian; Muralidharan Sargurupremraj; Nabi Shah; Praveen Surendran; Sébastien Thériault; Niek Verweij; Sara M Willems; Jing-Hua Zhao; Philippe Amouyel; John Connell; Renée de Mutsert; Alex S F Doney; Martin Farrall; Cristina Menni; Andrew D Morris; Raymond Noordam; Guillaume Paré; Neil R Poulter; Denis C Shields; Alice Stanton; Simon Thom; Gonçalo Abecasis; Najaf Amin; Dan E Arking; Kristin L Ayers; Caterina M Barbieri; Chiara Batini; Joshua C Bis; Tineka Blake; Murielle Bochud; Michael Boehnke; Eric Boerwinkle; Dorret I Boomsma; Erwin P Bottinger; Peter S Braund; Marco Brumat; Archie Campbell; Harry Campbell; Aravinda Chakravarti; John C Chambers; Ganesh Chauhan; Marina Ciullo; Massimiliano Cocca; Francis Collins; Heather J Cordell; Gail Davies; Martin H de Borst; Eco J de Geus; Ian J Deary; Joris Deelen; Fabiola Del Greco M; Cumhur Yusuf Demirkale; Marcus Dörr; Georg B Ehret; Roberto Elosua; Stefan Enroth; A Mesut Erzurumluoglu; Teresa Ferreira; Mattias Frånberg; Oscar H Franco; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Christian Gieger; Giorgia Girotto; Anuj Goel; Alan J Gow; Vilmundur Gudnason; Xiuqing Guo; Ulf Gyllensten; Anders Hamsten; Tamara B Harris; Sarah E Harris; Catharina A Hartman; Aki S Havulinna; Andrew A Hicks; Edith Hofer; Albert Hofman; Jouke-Jan Hottenga; Jennifer E Huffman; Shih-Jen Hwang; Erik Ingelsson; Alan James; Rick Jansen; Marjo-Riitta Jarvelin; Roby Joehanes; Åsa Johansson; Andrew D Johnson; Peter K Joshi; Pekka Jousilahti; J Wouter Jukema; Antti Jula; Mika Kähönen; Sekar Kathiresan; Bernard D Keavney; Kay-Tee Khaw; Paul Knekt; Joanne Knight; Ivana Kolcic; Jaspal S Kooner; Seppo Koskinen; Kati Kristiansson; Zoltan Kutalik; Maris Laan; Marty Larson; Lenore J Launer; Benjamin Lehne; Terho Lehtimäki; David C M Liewald; Li Lin; Lars Lind; Cecilia M Lindgren; YongMei Liu; Ruth J F Loos; Lorna M Lopez; Yingchang Lu; Leo-Pekka Lyytikäinen; Anubha Mahajan; Chrysovalanto Mamasoula; Jaume Marrugat; Jonathan Marten; Yuri Milaneschi; Anna Morgan; Andrew P Morris; Alanna C Morrison; Peter J Munson; Mike A Nalls; Priyanka Nandakumar; Christopher P Nelson; Teemu Niiranen; Ilja M Nolte; Teresa Nutile; Albertine J Oldehinkel; Ben A Oostra; Paul F O'Reilly; Elin Org; Sandosh Padmanabhan; Walter Palmas; Aarno Palotie; Alison Pattie; Brenda W J H Penninx; Markus Perola; Annette Peters; Ozren Polasek; Peter P Pramstaller; Quang Tri Nguyen; Olli T Raitakari; Meixia Ren; Rainer Rettig; Kenneth Rice; Paul M Ridker; Janina S Ried; Harriëtte Riese; Samuli Ripatti; Antonietta Robino; Lynda M Rose; Jerome I Rotter; Igor Rudan; Daniela Ruggiero; Yasaman Saba; Cinzia F Sala; Veikko Salomaa; Nilesh J Samani; Antti-Pekka Sarin; Reinhold Schmidt; Helena Schmidt; Nick Shrine; David Siscovick; Albert V Smith; Harold Snieder; Siim Sõber; Rossella Sorice; John M Starr; David J Stott; David P Strachan; Rona J Strawbridge; Johan Sundström; Morris A Swertz; Kent D Taylor; Alexander Teumer; Martin D Tobin; Maciej Tomaszewski; Daniela Toniolo; Michela Traglia; Stella Trompet; Jaakko Tuomilehto; Christophe Tzourio; André G Uitterlinden; Ahmad Vaez; Peter J van der Most; Cornelia M van Duijn; Anne-Claire Vergnaud; Germaine C Verwoert; Veronique Vitart; Uwe Völker; Peter Vollenweider; Dragana Vuckovic; Hugh Watkins; Sarah H Wild; Gonneke Willemsen; James F Wilson; Alan F Wright; Jie Yao; Tatijana Zemunik; Weihua Zhang; John R Attia; Adam S Butterworth; Daniel I Chasman; David Conen; Francesco Cucca; John Danesh; Caroline Hayward; Joanna M M Howson; Markku Laakso; Edward G Lakatta; Claudia Langenberg; Olle Melander; Dennis O Mook-Kanamori; Colin N A Palmer; Lorenz Risch; Robert A Scott; Rodney J Scott; Peter Sever; Tim D Spector; Pim van der Harst; Nicholas J Wareham; Eleftheria Zeggini; Daniel Levy; Patricia B Munroe; Christopher Newton-Cheh; Morris J Brown; Andres Metspalu; Adriana M Hung; Christopher J O'Donnell; Todd L Edwards; Bruce M Psaty; Ioanna Tzoulaki; Michael R Barnes; Louise V Wain; Paul Elliott; Mark J Caulfield
Journal:  Nat Genet       Date:  2018-09-17       Impact factor: 41.307

10.  An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Authors:  Robert A Scott; Laura J Scott; Reedik Mägi; Letizia Marullo; Kyle J Gaulton; Marika Kaakinen; Natalia Pervjakova; Tune H Pers; Andrew D Johnson; John D Eicher; Anne U Jackson; Teresa Ferreira; Yeji Lee; Clement Ma; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; Lu Qi; Natalie R Van Zuydam; Anubha Mahajan; Han Chen; Peter Almgren; Ben F Voight; Harald Grallert; Martina Müller-Nurasyid; Janina S Ried; Nigel W Rayner; Neil Robertson; Lennart C Karssen; Elisabeth M van Leeuwen; Sara M Willems; Christian Fuchsberger; Phoenix Kwan; Tanya M Teslovich; Pritam Chanda; Man Li; Yingchang Lu; Christian Dina; Dorothee Thuillier; Loic Yengo; Longda Jiang; Thomas Sparso; Hans A Kestler; Himanshu Chheda; Lewin Eisele; Stefan Gustafsson; Mattias Frånberg; Rona J Strawbridge; Rafn Benediktsson; Astradur B Hreidarsson; Augustine Kong; Gunnar Sigurðsson; Nicola D Kerrison; Jian'an Luan; Liming Liang; Thomas Meitinger; Michael Roden; Barbara Thorand; Tõnu Esko; Evelin Mihailov; Caroline Fox; Ching-Ti Liu; Denis Rybin; Bo Isomaa; Valeriya Lyssenko; Tiinamaija Tuomi; David J Couper; James S Pankow; Niels Grarup; Christian T Have; Marit E Jørgensen; Torben Jørgensen; Allan Linneberg; Marilyn C Cornelis; Rob M van Dam; David J Hunter; Peter Kraft; Qi Sun; Sarah Edkins; Katharine R Owen; John R B Perry; Andrew R Wood; Eleftheria Zeggini; Juan Tajes-Fernandes; Goncalo R Abecasis; Lori L Bonnycastle; Peter S Chines; Heather M Stringham; Heikki A Koistinen; Leena Kinnunen; Bengt Sennblad; Thomas W Mühleisen; Markus M Nöthen; Sonali Pechlivanis; Damiano Baldassarre; Karl Gertow; Steve E Humphries; Elena Tremoli; Norman Klopp; Julia Meyer; Gerald Steinbach; Roman Wennauer; Johan G Eriksson; Satu Mӓnnistö; Leena Peltonen; Emmi Tikkanen; Guillaume Charpentier; Elodie Eury; Stéphane Lobbens; Bruna Gigante; Karin Leander; Olga McLeod; Erwin P Bottinger; Omri Gottesman; Douglas Ruderfer; Matthias Blüher; Peter Kovacs; Anke Tonjes; Nisa M Maruthur; Chiara Scapoli; Raimund Erbel; Karl-Heinz Jöckel; Susanne Moebus; Ulf de Faire; Anders Hamsten; Michael Stumvoll; Panagiotis Deloukas; Peter J Donnelly; Timothy M Frayling; Andrew T Hattersley; Samuli Ripatti; Veikko Salomaa; Nancy L Pedersen; Bernhard O Boehm; Richard N Bergman; Francis S Collins; Karen L Mohlke; Jaakko Tuomilehto; Torben Hansen; Oluf Pedersen; Inês Barroso; Lars Lannfelt; Erik Ingelsson; Lars Lind; Cecilia M Lindgren; Stephane Cauchi; Philippe Froguel; Ruth J F Loos; Beverley Balkau; Heiner Boeing; Paul W Franks; Aurelio Barricarte Gurrea; Domenico Palli; Yvonne T van der Schouw; David Altshuler; Leif C Groop; Claudia Langenberg; Nicholas J Wareham; Eric Sijbrands; Cornelia M van Duijn; Jose C Florez; James B Meigs; Eric Boerwinkle; Christian Gieger; Konstantin Strauch; Andres Metspalu; Andrew D Morris; Colin N A Palmer; Frank B Hu; Unnur Thorsteinsdottir; Kari Stefansson; Josée Dupuis; Andrew P Morris; Michael Boehnke; Mark I McCarthy; Inga Prokopenko
Journal:  Diabetes       Date:  2017-05-31       Impact factor: 9.337
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  15 in total

1.  Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height.

Authors:  Mingjian Shi; Ali M Manouchehri; Christian M Shaffer; Nataraja Sarma Vaitinadin; Jacklyn N Hellwege; Joe-Elie Salem; Lea K Davis; Jill H Simmons; Dan M Roden; M Benjamin Shoemaker; Jane F Ferguson; Jonathan D Mosley
Journal:  J Clin Endocrinol Metab       Date:  2021-06-16       Impact factor: 5.958

2.  Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study.

Authors:  Christina Ellervik; Samia Mora; Aleksander Kuś; Bjørn Åsvold; Eirini Marouli; Panos Deloukas; Rosalie B T M Sterenborg; Alexander Teumer; Stephen Burgess; Maria Sabater-Lleal; Jennifer Huffman; Andrew D Johnson; David-Alexandre Trégouet; Nicolas L Smith; Marco Medici; Paul S DeVries; Daniel I Chasman; Alisa D Kjaergaard
Journal:  Thyroid       Date:  2021-08-05       Impact factor: 6.506

3.  Thyroid Function and Mood Disorders: A Mendelian Randomization Study.

Authors:  Aleksander Kuś; Alisa D Kjaergaard; Eirini Marouli; Fabiola Del Greco M; Rosalie B T M Sterenborg; Layal Chaker; Robin P Peeters; Tomasz Bednarczuk; Bjørn O Åsvold; Stephen Burgess; Panos Deloukas; Alexander Teumer; Christina Ellervik; Marco Medici
Journal:  Thyroid       Date:  2021-05-26       Impact factor: 6.506

4.  Does Maternal Normal Range Thyroid Function Play a Role in Offspring Birth Weight? Evidence From a Mendelian Randomization Analysis.

Authors:  Xinghao Zhang; Pengfei Wu; Yuyao Chen; Wan Zhang; Kun Xia; Huiyu Hu; Ping Zhou
Journal:  Front Endocrinol (Lausanne)       Date:  2020-11-12       Impact factor: 5.555

5.  Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank.

Authors:  Nicolien A van Vliet; Annelies E P Kamphuis; Wendy P J den Elzen; Gerard J Blauw; Jacobijn Gussekloo; Raymond Noordam; Diana van Heemst
Journal:  J Clin Endocrinol Metab       Date:  2022-01-18       Impact factor: 5.958

6.  CD11c+ B Cells Participate in the Pathogenesis of Graves' Disease by Secreting Thyroid Autoantibodies and Cytokines.

Authors:  Yedi Cao; Xue Zhao; Ran You; Yang Zhang; Chenxue Qu; Youyuan Huang; Yang Yu; Yan Gong; Tiechuan Cong; Enmin Zhao; Lanbo Zhang; Ying Gao; Junqing Zhang
Journal:  Front Immunol       Date:  2022-03-21       Impact factor: 7.561

7.  Thyroid Hormone Therapy and Incident Stroke.

Authors:  Maria Papaleontiou; Deborah A Levine; David Reyes-Gastelum; Sarah T Hawley; Mousumi Banerjee; Megan R Haymart
Journal:  J Clin Endocrinol Metab       Date:  2021-09-27       Impact factor: 6.134

8.  Association of Thyroid Function with Blood Pressure and Cardiovascular Disease: A Mendelian Randomization.

Authors:  Alice Giontella; Luca A Lotta; John D Overton; Aris Baras; Andrea Sartorio; Pietro Minuz; Dipender Gill; Olle Melander; Cristiano Fava
Journal:  J Pers Med       Date:  2021-12-06

9.  Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling.

Authors:  Nicolien A van Vliet; Maxime M Bos; Carisha S Thesing; Layal Chaker; Maik Pietzner; Evelyn Houtman; Matt J Neville; Ruifang Li-Gao; Stella Trompet; Rima Mustafa; Fariba Ahmadizar; Marian Beekman; Mariska Bot; Kathrin Budde; Constantinos Christodoulides; Abbas Dehghan; Christian Delles; Paul Elliott; Marina Evangelou; He Gao; Mohsen Ghanbari; Antonius E van Herwaarden; M Arfan Ikram; Martin Jaeger; J Wouter Jukema; Ibrahim Karaman; Fredrik Karpe; Margreet Kloppenburg; Jennifer M T A Meessen; Ingrid Meulenbelt; Yuri Milaneschi; Simon P Mooijaart; Dennis O Mook-Kanamori; Mihai G Netea; Romana T Netea-Maier; Robin P Peeters; Brenda W J H Penninx; Naveed Sattar; P Eline Slagboom; H Eka D Suchiman; Henry Völzke; Ko Willems van Dijk; Raymond Noordam; Diana van Heemst
Journal:  BMC Med       Date:  2021-11-03       Impact factor: 11.150

10.  A Deeper Understanding of the Causal Relationships Between Thyroid Function and Atrial Fibrillation.

Authors:  Aleksander Kuś; Alexander Teumer; Marco Medici
Journal:  J Clin Endocrinol Metab       Date:  2022-01-01       Impact factor: 5.958
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