| Literature DB >> 32359158 |
Pooja Middha Kapoor1,2, Nasim Mavaddat3, Parichoy Pal Choudhury4, Amber N Wilcox4,5, Sara Lindström6,7, Sabine Behrens1, Kyriaki Michailidou3,8, Joe Dennis3, Manjeet K Bolla3, Qin Wang3, Audrey Jung1, Zomoroda Abu-Ful9, Thomas Ahearn4, Irene L Andrulis10,11, Hoda Anton-Culver12, Volker Arndt13, Kristan J Aronson14, Paul L Auer15,16, Laura E Beane Freeman4, Heiko Becher17,18, Matthias W Beckmann19, Alicia Beeghly-Fadiel20, Javier Benitez21,22, Leslie Bernstein23, Stig E Bojesen24,25,26, Hiltrud Brauch24,25,26,27,28,29, Hermann Brenner13,29,30, Thomas Brüning31, Qiuyin Cai20, Daniele Campa1,32, Federico Canzian33, Angel Carracedo34,35, Brian D Carter36, Jose E Castelao37, Stephen J Chanock4, Nilanjan Chatterjee4,38,39, Georgia Chenevix-Trench40, Christine L Clarke41, Fergus J Couch42, Angela Cox43, Simon S Cross44, Kamila Czene45, James Y Dai15, H Shelton Earp46, Arif B Ekici47, A Heather Eliassen48,49, Mikael Eriksson45, D Gareth Evans50,51, Peter A Fasching19,52, Jonine Figueroa4,53,54, Lin Fritschi55, Marike Gabrielson45, Manuela Gago-Dominguez34,56, Chi Gao49,57, Susan M Gapstur36, Mia M Gaudet36, Graham G Giles24,25,26,27,28,29,58,59,60, Anna González-Neira22, Pascal Guénel61, Lothar Haeberle62, Christopher A Haiman63, Niclas Håkansson64, Per Hall45,65, Ute Hamann66, Sigrid Hatse67, Jane Heyworth68, Bernd Holleczek69, Robert N Hoover4, John L Hopper59, Anthony Howell70, David J Hunter49,57,71, Esther M John72, Michael E Jones73, Rudolf Kaaks1, Renske Keeman74, Cari M Kitahara75, Yon-Dschun Ko76, Stella Koutros4, Allison W Kurian72, Diether Lambrechts77,78, Loic Le Marchand79, Eunjung Lee63, Flavio Lejbkowicz9, Martha Linet75, Jolanta Lissowska80, Ana Llaneza81, Robert J MacInnis58,59, Maria Elena Martinez56,82, Tabea Maurer83, Catriona McLean84, Susan L Neuhausen23, William G Newman50,51, Aaron Norman85, Katie M O'Brien86, Andrew F Olshan87, Janet E Olson85, Håkan Olsson88, Nick Orr89, Charles M Perou90, Guillermo Pita91, Eric C Polley85, Ross L Prentice15, Gad Rennert9, Hedy S Rennert9, Kathryn J Ruddy92, Dale P Sandler86, Christobel Saunders93, Minouk J Schoemaker73, Ben Schöttker13,94, Fredrick Schumacher95, Christopher Scott85, Rodney J Scott24,25,26,27,28,29,58,59,60,96,97,98, Xiao-Ou Shu20, Ann Smeets99, Melissa C Southey60,100,101, John J Spinelli102,103, Jennifer Stone59,104, Anthony J Swerdlow73,105, Rulla M Tamimi48,49,57, Jack A Taylor86,106, Melissa A Troester87, Celine M Vachon107, Elke M van Veen50,51, Xiaoliang Wang6,7, Clarice R Weinberg108, Caroline Weltens109, Walter Willett49,110,111, Stacey J Winham112, Alicja Wolk64,113, Xiaohong R Yang4, Wei Zheng20, Argyrios Ziogas12, Alison M Dunning114, Paul D P Pharoah3,114, Marjanka K Schmidt74,115, Peter Kraft49,57, Douglas F Easton3,114, Roger L Milne24,25,26,27,28,29,58,59,60,96,97,98, Montserrat García-Closas4, Jenny Chang-Claude1,83.
Abstract
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.Entities:
Mesh：
Substances：
Year: 2021 PMID： 32359158 PMCID： PMC7936056 DOI： 10.1093/jnci/djaa056
Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506