Dirk Rades1, Trang Nguyen2, Steven E Schild3. 1. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net. 2. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. 3. Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
Abstract
BACKGROUND/AIM: The number of elderly patients with cancer is growing and requires particular attention. These patients may benefit from personalized treatments. This study aimed to identify prognostic factors of survival for elderly patients (≥65 years) irradiated for brain metastases from urinary bladder cancer. PATIENTS AND METHODS: In 29 elderly patients treated with whole-brain radiotherapy (WBRT), seven factors were retrospectively analyzed regarding survival, namely dose-fractionation regimen, age, gender, Karnofsky performance score, number of brain metastases, extra-cranial metastases, and interval between cancer diagnosis and WBRT. RESULTS: For the whole series, survival was 38% at 3 months and 21% at 6 months. Karnofsky performance score ≥70% showed a trend for being associated with improved survival when compared to ≤60%; survival rates were 50% vs. 29% at 3 months and 33% vs. 12% at 6 months (p=0.18). CONCLUSION: Karnofsky performance score may help estimate the survival of elderly patients irradiated for brain metastases from urinary bladder cancer. Copyright
BACKGROUND/AIM: The number of elderly patients with cancer is growing and requires particular attention. These patients may benefit from personalized treatments. This study aimed to identify prognostic factors of survival for elderly patients (≥65 years) irradiated for brain metastases from urinary bladder cancer. PATIENTS AND METHODS: In 29 elderly patients treated with whole-brain radiotherapy (WBRT), seven factors were retrospectively analyzed regarding survival, namely dose-fractionation regimen, age, gender, Karnofsky performance score, number of brain metastases, extra-cranial metastases, and interval between cancer diagnosis and WBRT. RESULTS: For the whole series, survival was 38% at 3 months and 21% at 6 months. Karnofsky performance score ≥70% showed a trend for being associated with improved survival when compared to ≤60%; survival rates were 50% vs. 29% at 3 months and 33% vs. 12% at 6 months (p=0.18). CONCLUSION: Karnofsky performance score may help estimate the survival of elderly patients irradiated for brain metastases from urinary bladder cancer. Copyright
Authors: Jasmin N Evers; Steven E Schild; Barbara Segedin; Viorica Nagy; Mai Trong Khoa; Ngo Thuy Trang; Dirk Rades Journal: Anticancer Res Date: 2014-05 Impact factor: 2.480
Authors: Dirk Rades; Liesa Dziggel; Lisa Manig; Stefan Janssen; Mai Trong Khoa; Vuong Ngoc Duong; Vu Huu Khiem; Steven E Schild Journal: In Vivo Date: 2018 May-Jun Impact factor: 2.155