Adarsh Bhimraj1, Rebecca L Morgan2, Amy Hirsch Shumaker3, Valery Lavergne4, Lindsey Baden5, Vincent Chi-Chung Cheng6, Kathryn M Edwards7, Rajesh Gandhi8, William J Muller9, John C O'Horo10, Shmuel Shoham11, M Hassan Murad12, Reem A Mustafa13, Shahnaz Sultan14, Yngve Falck-Ytter3. 1. Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio. 2. Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario. 3. VA Northeast Ohio Healthcare System, Case Western Reserve University School of Medicine, Cleveland, Ohio. 4. Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada. 5. Brigham and Women's Hospital, Boston, Massachusetts. 6. Queen Mary Hospital, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. 7. Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee. 8. Infectious Diseases Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. 9. Division of Pediatric Infectious Diseases, Northwestern University, Chicago, Illinois. 10. Division of Infectious Diseases, Joint Appointment Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota. 11. Johns Hopkins University School of Medicine, Baltimore, Maryland. 12. Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota. 13. Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas. 14. Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis VA Healthcare System, Minneapolis, Minnesota.
Abstract
BACKGROUND: There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. OBJECTIVE: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. METHODS: IDSA formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and grey literature was conducted. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence and make recommendations. RESULTS: The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations. CONCLUSIONS: The panel expressed the overarching goal that patients be recruited into ongoing trials, which would provide much needed evidence on the efficacy and safety of various therapies for COVID-19, given that we could not make a determination whether the benefits outweigh harms for most treatments.
BACKGROUND: There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. OBJECTIVE: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. METHODS: IDSA formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and grey literature was conducted. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence and make recommendations. RESULTS: The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations. CONCLUSIONS: The panel expressed the overarching goal that patients be recruited into ongoing trials, which would provide much needed evidence on the efficacy and safety of various therapies for COVID-19, given that we could not make a determination whether the benefits outweigh harms for most treatments.
Authors: Wesley H Self; Matthew W Semler; Lindsay M Leither; Jonathan D Casey; Derek C Angus; Roy G Brower; Steven Y Chang; Sean P Collins; John C Eppensteiner; Michael R Filbin; D Clark Files; Kevin W Gibbs; Adit A Ginde; Michelle N Gong; Frank E Harrell; Douglas L Hayden; Catherine L Hough; Nicholas J Johnson; Akram Khan; Christopher J Lindsell; Michael A Matthay; Marc Moss; Pauline K Park; Todd W Rice; Bryce R H Robinson; David A Schoenfeld; Nathan I Shapiro; Jay S Steingrub; Christine A Ulysse; Alexandra Weissman; Donald M Yealy; B Taylor Thompson; Samuel M Brown; Jay Steingrub; Howard Smithline; Bogdan Tiru; Mark Tidswell; Lori Kozikowski; Sherell Thornton-Thompson; Leslie De Souza; Peter Hou; Rebecca Baron; Anthony Massaro; Imoigele Aisiku; Lauren Fredenburgh; Raghu Seethala; Lily Johnsky; Richard Riker; David Seder; Teresa May; Michael Baumann; Ashley Eldridge; Christine Lord; Nathan Shapiro; Daniel Talmor; Thomas O’Mara; Charlotte Kirk; Kelly Harrison; Lisa Kurt; Margaret Schermerhorn; Valerie Banner-Goodspeed; Katherine Boyle; Nicole Dubosh; Michael Filbin; Kathryn Hibbert; Blair Parry; Kendall Lavin-Parsons; Natalie Pulido; Brendan Lilley; Carl Lodenstein; Justin Margolin; Kelsey Brait; Alan Jones; James Galbraith; Rebekah Peacock; Utsav Nandi; Taylor Wachs; Michael Matthay; Kathleen Liu; Kirsten Kangelaris; Ralph Wang; Carolyn Calfee; Kimberly Yee; Gregory Hendey; Steven Chang; George Lim; Nida Qadir; Andrea Tam; Rebecca Beutler; Joseph Levitt; Jenny Wilson; Angela Rogers; Rosemary Vojnik; Jonasel Roque; Timothy Albertson; James Chenoweth; Jason Adams; Skyler Pearson; Maya Juarez; Eyad Almasri; Mohamed Fayed; Alyssa Hughes; Shelly Hillard; Ryan Huebinger; Henry Wang; Elizabeth Vidales; Bela Patel; Adit Ginde; Marc Moss; Amiran Baduashvili; Jeffrey McKeehan; Lani Finck; Carrie Higgins; Michelle Howell; Ivor Douglas; Jason Haukoos; Terra Hiller; Carolynn Lyle; Alicia Cupelo; Emily Caruso; Claudia Camacho; Stephanie Gravitz; James Finigan; Christine Griesmer; Pauline Park; Robert Hyzy; Kristine Nelson; Kelli McDonough; Norman Olbrich; Mark Williams; Raj Kapoor; Jean Nash; Meghan Willig; Henry Ford; Jayna Gardner-Gray; Mayur Ramesh; Montefiore Moses; Michelle Ng Gong; Michael Aboodi; Ayesha Asghar; Omowunmi Amosu; Madeline Torres; Savneet Kaur; Jen-Ting Chen; Aluko Hope; Brenda Lopez; Kathleen Rosales; Jee Young You; Jarrod Mosier; Cameron Hypes; Bhupinder Natt; Bryan Borg; Elizabeth Salvagio Campbell; R Duncan Hite; Kristin Hudock; Autumn Cresie; Faysal Alhasan; Jose Gomez-Arroyo; Abhijit Duggal; Omar Mehkri; Andrei Hastings; Debasis Sahoo; Francois Abi Fadel; Susan Gole; Valerie Shaner; Allison Wimer; Yvonne Meli; Alexander King; Thomas Terndrup; Matthew Exline; Sonal Pannu; Emily Robart; Sarah Karow; Catherine Hough; Bryce Robinson; Nicholas Johnson; Daniel Henning; Monica Campo; Stephanie Gundel; Sakshi Seghal; Sarah Katsandres; Sarah Dean; Akram Khan; Olivia Krol; Milad Jouzestani; Peter Huynh; Alexandra Weissman; Donald Yealy; Denise Scholl; Peter Adams; Bryan McVerry; David Huang; Derek Angus; Jordan Schooler; Steven Moore; Clark Files; Chadwick Miller; Kevin Gibbs; Mary LaRose; Lori Flores; Lauren Koehler; Caryn Morse; John Sanders; Caitlyn Langford; Kristen Nanney; Masiku MdalaGausi; Phyllis Yeboah; Peter Morris; Jamie Sturgill; Sherif Seif; Evan Cassity; Sanjay Dhar; Marjolein de Wit; Jessica Mason; Andrew Goodwin; Greg Hall; Abbey Grady; Amy Chamberlain; Samuel Brown; Joseph Bledsoe; Lindsay Leither; Ithan Peltan; Nathan Starr; Melissa Fergus; Valerie Aston; Quinn Montgomery; Rilee Smith; Mardee Merrill; Katie Brown; Brent Armbruster; Estelle Harris; Elizabeth Middleton; Robert Paine; Stacy Johnson; Macy Barrios; John Eppensteiner; Alexander Limkakeng; Lauren McGowan; Tedra Porter; Andrew Bouffler; J. Clancy Leahy; Bennet deBoisblanc; Matthew Lammi; Kyle Happel; Paula Lauto; Wesley Self; Jonathan Casey; Matthew Semler; Sean Collins; Frank Harrell; Christopher Lindsell; Todd Rice; William Stubblefield; Christopher Gray; Jakea Johnson; Megan Roth; Margaret Hays; Donna Torr; Arwa Zakaria; David Schoenfeld; Taylor Thompson; Douglas Hayden; Nancy Ringwood; Cathryn Oldmixon; Christine Ulysse; Richard Morse; Ariela Muzikansky; Laura Fitzgerald; Samuel Whitaker; Adrian Lagakos; Roy Brower; Lora Reineck; Neil Aggarwal; Karen Bienstock; Michelle Freemer; Myron Maclawiw; Gail Weinmann; Laurie Morrison; Mark Gillespie; Richard Kryscio; Daniel Brodie; Wojciech Zareba; Anne Rompalo; Michael Boeckh; Polly Parsons; Jason Christie; Jesse Hall; Nicholas Horton; Laurie Zoloth; Neal Dickert; Deborah Diercks Journal: JAMA Date: 2020-12-01 Impact factor: 56.272
Authors: Nicholas J Mercuro; Christina F Yen; David J Shim; Timothy R Maher; Christopher M McCoy; Peter J Zimetbaum; Howard S Gold Journal: JAMA Cardiol Date: 2020-09-01 Impact factor: 14.676
Authors: Jennifer A Frontera; Sakinah Sabadia; Rebecca Lalchan; Taolin Fang; Brent Flusty; Patricio Millar-Vernetti; Thomas Snyder; Stephen Berger; Dixon Yang; Andre Granger; Nicole Morgan; Palak Patel; Josef Gutman; Kara Melmed; Shashank Agarwal; Matthew Bokhari; Andres Andino; Eduard Valdes; Mirza Omari; Alexandra Kvernland; Kaitlyn Lillemoe; Sherry H-Y Chou; Molly McNett; Raimund Helbok; Shraddha Mainali; Ericka L Fink; Courtney Robertson; Michelle Schober; Jose I Suarez; Wendy Ziai; David Menon; Daniel Friedman; David Friedman; Manisha Holmes; Joshua Huang; Sujata Thawani; Jonathan Howard; Nada Abou-Fayssal; Penina Krieger; Ariane Lewis; Aaron S Lord; Ting Zhou; D Ethan Kahn; Barry M Czeisler; Jose Torres; Shadi Yaghi; Koto Ishida; Erica Scher; Adam de Havenon; Dimitris Placantonakis; Mengling Liu; Thomas Wisniewski; Andrea B Troxel; Laura Balcer; Steven Galetta Journal: Neurology Date: 2020-10-05 Impact factor: 9.910