| Literature DB >> 32326758 |
Sei W Kim1, In K Kim1,2, Sang H Lee1,2.
Abstract
IMPACT STATEMENT: Tumor hypoxia promotes cancer cell aggressiveness, and is strongly associated with poor prognosis across multiple tumor types. The hypoxic microenvironments inside tumors also limit the effectiveness of radiotherapy, chemotherapy, and immunotherapy. Several approaches to eliminate hypoxic state in tumors have been proposed to delay cancer progression and improve therapeutic efficacies. This review will summarize current knowledge on hyperoxia, used alone or in combination with other therapeutic modalities, in cancer treatment. Molecular mechanisms and undesired side effects of hyperoxia will also be discussed.Entities:
Keywords: Neoplasms; antitumor effect; hyperoxia; oxidative stress; oxygen; reactive oxygen species
Mesh：
Year: 2020 PMID： 32326758 PMCID： PMC7268933 DOI： 10.1177/1535370220921547
Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699