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Literature DB >> 27824512

Hypoxia: A Double-Edged Sword in Cancer Therapy.

Hamed Manoochehri Khoshinani¹, Saeid Afshar¹, Rezvan Najafi¹.

Abstract

Hypoxia is a common feature of malignant tumors. There is an interactive connection between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis. Therefore, tumor hypoxia has been considered as a validated target for treating cancer. This review focuses on the role of hypoxia on chemoresistance and radioresistance. In addition, we address several approaches targeting tumor hypoxia, known as hypoxia-targeted therapy.

Entities: Disease

Keywords: Chemoresistance; HIF-1; Hypoxia; Hypoxia-targeted therapy; Radioresistance

Mesh：

Substances：

Year: 2016 PMID： 27824512 DOI： 10.1080/07357907.2016.1245317

Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176

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