Literature DB >> 24099156

Transcriptional regulation by hypoxia inducible factors.

Veronica L Dengler1, Matthew Galbraith1, Joaquín M Espinosa1.   

Abstract

The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.

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Year:  2013        PMID： 24099156      PMCID： PMC4342852          DOI： 10.3109/10409238.2013.838205

Source DB:  PubMed          Journal:  Crit Rev Biochem Mol Biol        ISSN： 1040-9238            Impact factor:   8.250


  173 in total

Review 1.  Passing the baton: the HIF switch.

Authors:  Mei Yee Koh; Garth Powis
Journal:  Trends Biochem Sci       Date:  2012-07-18       Impact factor: 13.807

2.  HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels.

Authors:  I Flamme; T Fröhlich; M von Reutern; A Kappel; A Damert; W Risau
Journal:  Mech Dev       Date:  1997-04       Impact factor: 1.882

Review 3.  Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.

Authors:  Gregg L Semenza
Journal:  Trends Pharmacol Sci       Date:  2012-03-06       Impact factor: 14.819

4.  Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.

Authors:  Eric V Dang; Joseph Barbi; Huang-Yu Yang; Dilini Jinasena; Hong Yu; Ying Zheng; Zachary Bordman; Juan Fu; Young Kim; Hung-Rong Yen; Weibo Luo; Karen Zeller; Larissa Shimoda; Suzanne L Topalian; Gregg L Semenza; Chi V Dang; Drew M Pardoll; Fan Pan
Journal:  Cell       Date:  2011-08-25       Impact factor: 41.582

5.  Negative regulation of hypoxic responses via induced Reptin methylation.

Authors:  Jason S Lee; Yunho Kim; Ik Soo Kim; Bogyou Kim; Hee June Choi; Ji Min Lee; Hi-Jai R Shin; Jung Hwa Kim; Ji-Young Kim; Sang-Beom Seo; Ho Lee; Olivier Binda; Or Gozani; Gregg L Semenza; Minhyung Kim; Keun Il Kim; Daehee Hwang; Sung Hee Baek
Journal:  Mol Cell       Date:  2010-07-09       Impact factor: 17.970

Review 6.  HIF-1: the knowns and unknowns of hypoxia sensing.

Authors:  Anna Zagórska; Józef Dulak
Journal:  Acta Biochim Pol       Date:  2004       Impact factor: 2.149

7.  Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia.

Authors:  Andrés Dekanty; Nuria M Romero; Agustina P Bertolin; María G Thomas; Claudia C Leishman; Joel I Perez-Perri; Graciela L Boccaccio; Pablo Wappner
Journal:  PLoS Genet       Date:  2010-06-24       Impact factor: 5.917

8.  Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator.

Authors:  Eric S Tien; John W Davis; John P Vanden Heuvel
Journal:  J Biol Chem       Date:  2004-03-29       Impact factor: 5.157

9.  HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

Authors:  Kelly L Covello; James Kehler; Hongwei Yu; John D Gordan; Andrew M Arsham; Cheng-Jun Hu; Patricia A Labosky; M Celeste Simon; Brian Keith
Journal:  Genes Dev       Date:  2006-03-01       Impact factor: 11.361

10.  Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction.

Authors:  Amaya Ortiz-Barahona; Diego Villar; Nuria Pescador; Jorge Amigo; Luis del Peso
Journal:  Nucleic Acids Res       Date:  2010-01-08       Impact factor: 16.971
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  237 in total

1.  Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2.

Authors:  Ang Luo; Yue Chen
Journal:  J Proteome Res       Date:  2019-12-06       Impact factor: 4.466

Review 2.  Role of hyperoxic treatment in cancer.

Authors:  Sei W Kim; In K Kim; Sang H Lee
Journal:  Exp Biol Med (Maywood)       Date:  2020-04-23

3.  Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.

Authors:  Kellsye Paula L Fabian; Nina Chi-Sabins; Jennifer L Taylor; Ronald Fecek; Aliyah Weinstein; Walter J Storkus
Journal:  Oncoimmunology       Date:  2017-02-10       Impact factor: 8.110

Review 4.  The role of HIF proteins in maintaining the metabolic health of the intervertebral disc.

Authors:  Elizabeth S Silagi; Ernestina Schipani; Irving M Shapiro; Makarand V Risbud
Journal:  Nat Rev Rheumatol       Date:  2021-06-03       Impact factor: 20.543

5.  Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells.

Authors:  Jeff Klomp; James Hyun; Jennifer E Klomp; Kostandin Pajcini; Jalees Rehman; Asrar B Malik
Journal:  J Biol Chem       Date:  2020-02-18       Impact factor: 5.157

Review 6.  Inside the hypoxic tumour: reprogramming of the DDR and radioresistance.

Authors:  Katheryn Begg; Mahvash Tavassoli
Journal:  Cell Death Discov       Date:  2020-08-18

7.  Differential but Complementary HIF1α and HIF2α Transcriptional Regulation.

Authors:  Nicholas L Downes; Nihay Laham-Karam; Minna U Kaikkonen; Seppo Ylä-Herttuala
Journal:  Mol Ther       Date:  2018-05-09       Impact factor: 11.454

Review 8.  The role of hypoxia-inducible factors in metabolic diseases.

Authors:  Frank J Gonzalez; Cen Xie; Changtao Jiang
Journal:  Nat Rev Endocrinol       Date:  2018-12       Impact factor: 43.330

9.  Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA.

Authors:  Dongjian Hu; Annet Linders; Abir Yamak; Cláudia Correia; Jan David Kijlstra; Arman Garakani; Ling Xiao; David J Milan; Peter van der Meer; Margarida Serra; Paula M Alves; Ibrahim J Domian
Journal:  Circ Res       Date:  2018-10-12       Impact factor: 17.367

10.  Anemia in infancy is associated with alterations in systemic metabolism and microbial structure and function in a sex-specific manner: an observational study.

Authors:  Shannon McClorry; Nelly Zavaleta; Alejandro Llanos; Martin Casapía; Bo Lönnerdal; Carolyn M Slupsky
Journal:  Am J Clin Nutr       Date:  2018-12-01       Impact factor: 7.045
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