Chinedum Eleazu1,2, Joseph Bagi Suleiman2,3, Zaidatul Akmal Othman2,4, Zaida Zakaria2, Victor Udo Nna2,5, Nik Hazlina Nik Hussain6, Mahaneem Mohamed2,7. 1. Department of Chemistry, Biochemistry and Molecular Biology, Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State, Nigeria. 2. Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. 3. Department of Science Laboratory Technology, Akanu Ibiam Federal Polytechnic, Unwana, Ebonyi State, Nigeria. 4. Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Terengganu, Malaysia. 5. Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria. 6. Women's Health Development Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. 7. Unit of Integrative Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Abstract
CONTEXT: Global prevalence of obesity is increasing. OBJECTIVE: To study the effect of bee bread (BB) on serum renal function parameters, oxidative stress, inflammatory and B-cell associated protein X (Bax) in the kidneys of high fat diet (HFD) obese rats. METHODS: Thirty-six male Sprague Dawley rats were used. Control: received rat diet and water (1 mL/kg); HFD group: received HFD and water (1 mL/kg): bee bread (BB) preventive or orlistat preventive: received HFD and BB (0.5 g/kg) or HFD and orlistat (10 mg/kg); BB or orlistat treatment: received BB (0.5 g/kg) or orlistat (10 mg/kg). RESULTS: HFD group had increased body weight, Body Mass Index, Lee Obesity Indices, kidney weights, malondialdehyde, inflammatory markers, Bax; decreased glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, total antioxidant activity, no differences (p > .05) in food intakes, serum creatinine, sodium, potassium, chloride, catalase compared to control. CONCLUSION: BB modulated most of these parameters, as corroborated by histology.
CONTEXT: Global prevalence of obesity is increasing. OBJECTIVE: To study the effect of bee bread (BB) on serum renal function parameters, oxidative stress, inflammatory and B-cell associated protein X (Bax) in the kidneys of high fat diet (HFD) obese rats. METHODS: Thirty-six male Sprague Dawley rats were used. Control: received rat diet and water (1 mL/kg); HFD group: received HFD and water (1 mL/kg): bee bread (BB) preventive or orlistat preventive: received HFD and BB (0.5 g/kg) or HFD and orlistat (10 mg/kg); BB or orlistat treatment: received BB (0.5 g/kg) or orlistat (10 mg/kg). RESULTS: HFD group had increased body weight, Body Mass Index, Lee Obesity Indices, kidney weights, malondialdehyde, inflammatory markers, Bax; decreased glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, total antioxidant activity, no differences (p > .05) in food intakes, serum creatinine, sodium, potassium, chloride, catalase compared to control. CONCLUSION: BB modulated most of these parameters, as corroborated by histology.
Authors: Zaidatul Akmal Othman; Zaida Zakaria; Joseph Bagi Suleiman; Victor Udo Nna; Aminah Che Romli; Wan Syaheedah Wan Ghazali; Mahaneem Mohamed Journal: Int J Mol Sci Date: 2021-04-19 Impact factor: 5.923
Authors: Joseph Bagi Suleiman; Mahaneem Mohamed; Ainul Bahiyah Abu Bakar; Zaida Zakaria; Zaidatul Akmal Othman; Victor Udo Nna Journal: Antioxidants (Basel) Date: 2022-01-28
Authors: Zaida Zakaria; Zaidatul Akmal Othman; Joseph Bagi Suleiman; Nur Asyilla Che Jalil; Wan Syaheedah Wan Ghazali; Victor Udo Nna; Mahaneem Mohamed Journal: Antioxidants (Basel) Date: 2021-12-20