Literature DB >> 3229899

Liposome-bound cyclosporine: clearance after intravitreal injection.

A A Alghadyan1, G A Peyman, B Khoobehi, S Milner, K R Liu.   

Abstract

The concentration of cyclosporine in the vitreous after intravitreal injection of 100 micrograms of either free or liposome-bound cyclosporine was studied in albino rabbits. We found that the half-life of free cyclosporine was about 6 hours and that of liposome-bound cyclosporine was about 3 days. The finding indicates that liposome-bound cyclosporine prolongs the availability of the drug.

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Year:  1988        PMID： 3229899     DOI： 10.1007/bf00137135

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN： 0165-5701            Impact factor:   2.031


  13 in total

1.  Dissecting ocular tissue for intraocular drug studies.

Authors:  R Abel; G L Boyle
Journal:  Invest Ophthalmol       Date:  1976-03

2.  Penetration of topical cyclosporine into the rabbit cornea, aqueous humor, and serum.

Authors:  M W Mosteller; B M Gebhardt; A M Hamilton; H E Kaufman
Journal:  Arch Ophthalmol       Date:  1985-01

3.  Retinal toxicity study of intravitreal cyclosporin.

Authors:  J Grisolano; G A Peyman
Journal:  Ophthalmic Surg       Date:  1986-03

4.  Liposome-bound cyclosporine: aqueous and vitreous level after subconjunctival injection.

Authors:  A A Alghadyan; G A Peyman; B Khoobehi; S Milner; K R Liu
Journal:  Int Ophthalmol       Date:  1988       Impact factor: 2.031

5.  Suppression of secondary herpes simplex uveitis by cyclosporine.

Authors:  J O Oh; P Minasi; G Grabner; Y Ohashi
Journal:  Invest Ophthalmol Vis Sci       Date:  1985-04       Impact factor: 4.799

6.  Cyclosporin A: tissue levels following topical and systemic administration to rabbits.

Authors:  T A Bell; A G Hunnisett
Journal:  Br J Ophthalmol       Date:  1986-11       Impact factor: 4.638

7.  Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

Authors:  F Szoka; D Papahadjopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

8.  Pharmacokinetic of topical cyclosporin A in the rabbit eye.

Authors:  M Wiederholt; D Kössendrup; W Schulz; F Hoffmann
Journal:  Invest Ophthalmol Vis Sci       Date:  1986-04       Impact factor: 4.799

9.  Intravitreal liposome-encapsulated gentamicin in a rabbit model. Prolonged therapeutic levels.

Authors:  P H Fishman; G A Peyman; T Lesar
Journal:  Invest Ophthalmol Vis Sci       Date:  1986-07       Impact factor: 4.799

10.  Intravitreal liposome-encapsulated trifluorothymidine in a rabbit model.

Authors:  K R Liu; G A Peyman; B Khoobehi; H Alkan; R Fiscella
Journal:  Ophthalmology       Date:  1987-09       Impact factor: 12.079
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  8 in total

Review 1.  Recent advances in cyclosporine drug delivery: challenges and opportunities.

Authors:  Dhrumi Patel; Sarika Wairkar
Journal:  Drug Deliv Transl Res       Date:  2019-12       Impact factor: 4.617

2.  Ocular drug delivery systems: An overview.

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Review 3.  A comprehensive review of intravitreal immunosuppressants and biologicals used in ophthalmology.

Authors:  Nasiq Hasan; Rohan Chawla; Nawazish Shaikh; Sindhuja Kandasamy; Shorya Vardhan Azad; M Dheepak Sundar
Journal:  Ther Adv Ophthalmol       Date:  2022-05-18

4.  Corticosteroids and daunomycin in the prevention of experimental proliferative vitreoretinopathy induced by macrophages.

Authors:  Y N Hui; H C Liang; Y S Cai; B Kirchhof; K Heimann
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1993-02       Impact factor: 3.117

5.  Diabetic retinopathy - An update.

Authors:  Abdulrahman A Alghadyan
Journal:  Saudi J Ophthalmol       Date:  2011-01-31

Review 6.  Nanomedicines for back of the eye drug delivery, gene delivery, and imaging.

Authors:  Uday B Kompella; Aniruddha C Amrite; Rashmi Pacha Ravi; Shelley A Durazo
Journal:  Prog Retin Eye Res       Date:  2013-04-17       Impact factor: 21.198

7.  Recent applications of liposomes in ophthalmic drug delivery.

Authors:  Gyan P Mishra; Mahuya Bagui; Viral Tamboli; Ashim K Mitra
Journal:  J Drug Deliv       Date:  2011-03-01

8.  Supercritical fluid-mediated liposomes containing cyclosporin A for the treatment of dry eye syndrome in a rabbit model: comparative study with the conventional cyclosporin A emulsion.

Authors:  Pankaj Ranjan Karn; Hyun Do Kim; Han Kang; Bo Kyung Sun; Su-Eon Jin; Sung-Joo Hwang
Journal:  Int J Nanomedicine       Date:  2014-08-08
  8 in total

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