Literature DB >> 3960475

Retinal toxicity study of intravitreal cyclosporin.

J Grisolano, G A Peyman.   

Abstract

We investigated the toxicity of intravitreal cyclosporin in the rabbit. Histologic retinal changes were found with intravitreal injections of 200 micrograms. No histologic or electroretinographic changes were observed with doses of 100 micrograms or less. This nontoxic dose is projected to be at least 77 times the amount needed to be effective.

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Year:  1986        PMID： 3960475

Source DB:  PubMed          Journal:  Ophthalmic Surg        ISSN： 0022-023X


  6 in total

Review 1.  New developments in sustained release drug delivery for the treatment of intraocular disease.

Authors:  G Velez; S M Whitcup
Journal:  Br J Ophthalmol       Date:  1999-11       Impact factor: 4.638

2.  Intravitreal anti-inflammatory treatment for uveitis.

Authors:  S Sugita
Journal:  Br J Ophthalmol       Date:  2007-02       Impact factor: 4.638

3.  Liposome-bound cyclosporine: clearance after intravitreal injection.

Authors:  A A Alghadyan; G A Peyman; B Khoobehi; S Milner; K R Liu
Journal:  Int Ophthalmol       Date:  1988       Impact factor: 2.031

4.  Liposome-bound cyclosporine: retinal toxicity after intravitreal injection.

Authors:  A A Alghadyan; G A Peyman; B Khoobehi; K R Liu
Journal:  Int Ophthalmol       Date:  1988       Impact factor: 2.031

Review 5.  A comprehensive review of intravitreal immunosuppressants and biologicals used in ophthalmology.

Authors:  Nasiq Hasan; Rohan Chawla; Nawazish Shaikh; Sindhuja Kandasamy; Shorya Vardhan Azad; M Dheepak Sundar
Journal:  Ther Adv Ophthalmol       Date:  2022-05-18

Review 6.  An overview on dry eye treatment: approaches for cyclosporin a delivery.

Authors:  Burçin Yavuz; Sibel Bozdağ Pehlivan; Nurşen Unlü
Journal:  ScientificWorldJournal       Date:  2012-04-24
  6 in total

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