Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Advancing Cancer Research and Medicine with Single-Cell Genomics.

Literature DB >> 32289270

Advancing Cancer Research and Medicine with Single-Cell Genomics.

Abstract

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, and improved reproducibility, paving the way for clinical applications. However, before translational applications can be realized, there are a number of logistical and technical challenges that must be overcome. This review discusses past cancer research studies, emerging technologies, and future clinical applications that are bound to transform cancer medicine.

Entities: CellLine Chemical Disease Gene Species

Keywords: cancer evolution; intratumor heterogeneity; metastasis; single cell genomics; single cell sequencing; therapy resistance; translational genomics

Mesh：

Year: 2020 PMID： 32289270 PMCID： PMC7899145 DOI： 10.1016/j.ccell.2020.03.008

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

139 in total

1. Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.

Authors: Andrew S Venteicher; Itay Tirosh; Christine Hebert; Keren Yizhak; Cyril Neftel; Mariella G Filbin; Volker Hovestadt; Leah E Escalante; McKenzie L Shaw; Christopher Rodman; Shawn M Gillespie; Danielle Dionne; Christina C Luo; Hiranmayi Ravichandran; Ravindra Mylvaganam; Christopher Mount; Maristela L Onozato; Brian V Nahed; Hiroaki Wakimoto; William T Curry; A John Iafrate; Miguel N Rivera; Matthew P Frosch; Todd R Golub; Priscilla K Brastianos; Gad Getz; Anoop P Patel; Michelle Monje; Daniel P Cahill; Orit Rozenblatt-Rosen; David N Louis; Bradley E Bernstein; Aviv Regev; Mario L Suvà
Journal: Science Date: 2017-03-31 Impact factor: 47.728

2. Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia.

Authors: Martin Carroll; Catherine C Smith; Alexander E Perl; Christine M McMahon; Timothy Ferng; Jonathan Canaani; Eunice S Wang; Jennifer J D Morrissette; Dennis J Eastburn; Maurizio Pellegrino; Robert Durruthy-Durruthy; Christopher D Watt; Saurabh Asthana; Elisabeth A Lasater; RosaAnna DeFilippis; Cheryl A C Peretz; Lisa H F McGary; Safoora Deihimi; Aaron C Logan; Selina M Luger; Neil P Shah
Journal: Cancer Discov Date: 2019-05-14 Impact factor: 39.397

3. Genome-wide detection of single-nucleotide and copy-number variations of a single human cell.

Authors: Chenghang Zong; Sijia Lu; Alec R Chapman; X Sunney Xie
Journal: Science Date: 2012-12-21 Impact factor: 47.728

4. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance.

Authors: Svetlana Altshuler-Keylin; Kosaku Shinoda; Yutaka Hasegawa; Kenji Ikeda; Haemin Hong; Qianqian Kang; Yangyu Yang; Rushika M Perera; Jayanta Debnath; Shingo Kajimura
Journal: Cell Metab Date: 2016-08-25 Impact factor: 27.287

Review 5. Diagnostic strategies for unknown primary cancer.

Authors: Gauri R Varadhachary; James L Abbruzzese; Renato Lenzi
Journal: Cancer Date: 2004-05-01 Impact factor: 6.860

Review 6. The role of myeloid cells in cancer therapies.

Authors: Camilla Engblom; Christina Pfirschke; Mikael J Pittet
Journal: Nat Rev Cancer Date: 2016-07 Impact factor: 60.716

7. Somatic mutations and cell identity linked by Genotyping of Transcriptomes.

Authors: Anna S Nam; Kyu-Tae Kim; Ronan Chaligne; Franco Izzo; Chelston Ang; Justin Taylor; Robert M Myers; Ghaith Abu-Zeinah; Ryan Brand; Nathaniel D Omans; Alicia Alonso; Caroline Sheridan; Marisa Mariani; Xiaoguang Dai; Eoghan Harrington; Alessandro Pastore; Juan R Cubillos-Ruiz; Wayne Tam; Ronald Hoffman; Raul Rabadan; Joseph M Scandura; Omar Abdel-Wahab; Peter Smibert; Dan A Landau
Journal: Nature Date: 2019-07-03 Impact factor: 49.962

8. Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.

Authors: Nicola Aceto; Aditya Bardia; David T Miyamoto; Maria C Donaldson; Ben S Wittner; Joel A Spencer; Min Yu; Adam Pely; Amanda Engstrom; Huili Zhu; Brian W Brannigan; Ravi Kapur; Shannon L Stott; Toshi Shioda; Sridhar Ramaswamy; David T Ting; Charles P Lin; Mehmet Toner; Daniel A Haber; Shyamala Maheswaran
Journal: Cell Date: 2014-08-28 Impact factor: 41.582

9. Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling.

Authors: Susanne Nichterwitz; Geng Chen; Julio Aguila Benitez; Marlene Yilmaz; Helena Storvall; Ming Cao; Rickard Sandberg; Qiaolin Deng; Eva Hedlund
Journal: Nat Commun Date: 2016-07-08 Impact factor: 14.919

10. The Human Cell Atlas.

Authors: Aviv Regev; Sarah A Teichmann; Eric S Lander; Ido Amit; Christophe Benoist; Ewan Birney; Bernd Bodenmiller; Peter Campbell; Piero Carninci; Menna Clatworthy; Hans Clevers; Bart Deplancke; Ian Dunham; James Eberwine; Roland Eils; Wolfgang Enard; Andrew Farmer; Lars Fugger; Berthold Göttgens; Nir Hacohen; Muzlifah Haniffa; Martin Hemberg; Seung Kim; Paul Klenerman; Arnold Kriegstein; Ed Lein; Sten Linnarsson; Emma Lundberg; Joakim Lundeberg; Partha Majumder; John C Marioni; Miriam Merad; Musa Mhlanga; Martijn Nawijn; Mihai Netea; Garry Nolan; Dana Pe'er; Anthony Phillipakis; Chris P Ponting; Stephen Quake; Wolf Reik; Orit Rozenblatt-Rosen; Joshua Sanes; Rahul Satija; Ton N Schumacher; Alex Shalek; Ehud Shapiro; Padmanee Sharma; Jay W Shin; Oliver Stegle; Michael Stratton; Michael J T Stubbington; Fabian J Theis; Matthias Uhlen; Alexander van Oudenaarden; Allon Wagner; Fiona Watt; Jonathan Weissman; Barbara Wold; Ramnik Xavier; Nir Yosef
Journal: Elife Date: 2017-12-05 Impact factor: 8.140

52 in total

Review 1. Computational analysis of cancer genome sequencing data.

Authors: Isidro Cortés-Ciriano; Doga C Gulhan; Jake June-Koo Lee; Giorgio E M Melloni; Peter J Park
Journal: Nat Rev Genet Date: 2021-12-08 Impact factor: 53.242

Review 2. Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential.

Authors: Ying Cao
Journal: Stem Cell Rev Rep Date: 2021-10-29 Impact factor: 5.739

3. Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts.

Authors: Hendrik J Kuiken; Sabin Dhakal; Laura M Selfors; Chandler M Friend; Tian Zhang; Maurizio Callari; Ron C J Schackmann; G Kenneth Gray; Jett Crowdis; Hyo-Eun C Bhang; Timour Baslan; Frank Stegmeier; Steven P Gygi; Carlos Caldas; Joan S Brugge
Journal: Oncogene Date: 2021-10-26 Impact factor: 9.867

Review 4. Untangling the web of intratumour heterogeneity.

Authors: Zheqi Li; Marco Seehawer; Kornelia Polyak
Journal: Nat Cell Biol Date: 2022-08-08 Impact factor: 28.213

Review 5. Practical Considerations for Single-Cell Genomics.

Authors: Claire Regan; Jonathan Preall
Journal: Curr Protoc Date: 2022-08

6. Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data.

Authors: Natalie C Fisher; Ryan M Byrne; Nigel B Jamieson; Philip D Dunne; Holly Leslie; Colin Wood; Assya Legrini; Andrew J Cameron; Baharak Ahmaderaghi; Shania M Corry; Sudhir B Malla; Raheleh Amirkhah; Aoife J McCooey; Emily Rogan; Keara L Redmond; Svetlana Sakhnevych; Enric Domingo; James Jackson; Maurice B Loughrey; Simon Leedham; Tim Maughan; Mark Lawler; Owen J Sansom; Felicity Lamrock; Viktor H Koelzer
Journal: Clin Cancer Res Date: 2022-09-15 Impact factor: 13.801