A Perspective on MR Fingerprinting.

This article reviews the basic concept of MR fingerprinting (MRF) with the goal of highlighting MRF's key contributions, putting them in the context of other quantitative MRI literature, and refining MRF's terminology. The article discusses the robustness and flexibility of MRF's signature dictionary-matching reconstruction along with more advanced MRF reconstructions. A key feature of MRF is the lack of assumptions about the signal evolution, which gives scientists the flexibility to tailor sequences for their needs. The article argues that the concept of unique fingerprints does not capture the requirements for successful parameter mapping and that an analysis of the signal's derivatives with respect to biophysical parameters, such as relaxation times, is more informative, as it allows one to evaluate the efficiency of a pulse sequence. The article points at the source of MRF's efficiency, namely, flip angle variations at the time scale of the relaxation times, and reveals that MRF's advantages are strongest at long scan times, as required for 3D imaging. Further, it outlines how MRF's flexibility can be used to design mutually tailored pulse sequences and biophysical models with the goal of improving the reproducibility of parameter mapping biological tissue. LEVEL OF EVIDENCE: 5 TECHNICAL EFFICACY STAGE: 1.