| Literature DB >> 32269166 |
Chia-Han Chiang1, Sang Min Won2, Amy L Orsborn3,4,5, Ki Jun Yu6, Michael Trumpis7, Brinnae Bent7, Charles Wang7, Yeguang Xue8,9, Seunghwan Min10, Virginia Woods7, Chunxiu Yu7,11, Bong Hoon Kim12,13, Sung Bong Kim14, Rizwan Huq15, Jinghua Li14,16,17, Kyung Jin Seo18, Flavia Vitale19,20, Andrew Richardson21, Hui Fang18, Yonggang Huang8,9,14,22, Kenneth Shepard15,23, Bijan Pesaran24,25, John A Rogers26,9,14,16,22,27,28,29,30, Jonathan Viventi1,31,32.
Abstract
Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating powered electronics to multiplex many electrodes to a few external wires. However, existing multiplexed electrode arrays rely on encapsulation strategies that have limited implant lifetimes. Here, we developed a flexible, multiplexed electrode array, called "Neural Matrix," that provides stable in vivo neural recordings in rodents and nonhuman primates. Neural Matrix lasts over a year and samples a centimeter-scale brain region using over a thousand channels. The long-lasting encapsulation (projected to last at least 6 years), scalable device design, and iterative in vivo optimization described here are essential components to overcoming current hurdles facing next-generation neural technologies.Entities:
Year: 2020 PMID： 32269166 PMCID： PMC7478122 DOI： 10.1126/scitranslmed.aay4682
Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956