Literature DB >> 3226469

The development of the muscarinic acetylcholine receptor in normal and hyperphenylalaninemic rat cerebrum.

K Matsuo1, F A Hommes.   

Abstract

The effect of hyperphenylalaninemia on the development of the muscarinic acetylcholine receptor in rat cerebrum has been studied. Rats were subjected to the hyperphenylalaninemic regimen as of 5 days of age. A gradual and steady decrease in the number of binding sites for L-[3H]quinuclidinylbenzilate was observed, with the white matter more affected than the gray matter. A return to normal blood phenylalanine levels after the age of 21 days does not lead to an increase in this number of binding sites.

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Year:  1988        PMID： 3226469     DOI： 10.1007/bf00970755

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  20 in total

1.  Effect of postweaning hyperphenylalaninemia on brain development in rats: myelination, lipid, and fatty acid composition of myelin.

Authors:  S N Shah; R C Johnson
Journal:  Exp Neurol       Date:  1978-09-01       Impact factor: 5.330

2.  On a possible mechanism of abnormal brain development in experimental hyperphenylalaninemia.

Authors:  F A Hommes; K Matsuo
Journal:  Neurochem Int       Date:  1987       Impact factor: 3.921

3.  Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats.

Authors:  O Greengard; M S Yoss; J A Del Valle
Journal:  Science       Date:  1976-06-04       Impact factor: 47.728

4.  Lipid composition of human cerebral white matter and myelin in phenylketonuria.

Authors:  S N Shah; N A Peterson; C M McKean
Journal:  J Neurochem       Date:  1972-10       Impact factor: 5.372

Review 5.  Mismatches between neurotransmitter and receptor localizations in brain: observations and implications.

Authors:  M Herkenham
Journal:  Neuroscience       Date:  1987-10       Impact factor: 3.590

6.  Brain protein and myelin metabolism in hyperphenylalaninemic rats.

Authors:  R Berger; J Springer; F A Hommes
Journal:  Cell Mol Biol Incl Cyto Enzymol       Date:  1980

7.  Postnatal development of cholinergic enzymes and receptors in mouse brain.

Authors:  E P Fiedler; M J Marks; A C Collins
Journal:  J Neurochem       Date:  1987-09       Impact factor: 5.372

8.  Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer's-type dementia brains.

Authors:  P Davies; A H Verth
Journal:  Brain Res       Date:  1977-12-16       Impact factor: 3.252

9.  Effect of experimental hyperphenylalaninemia on myelin metabolism at later stages of brain development.

Authors:  E H Taylor; F A Hommes
Journal:  Int J Neurosci       Date:  1983-09       Impact factor: 2.292

10.  Characterization of experimental phenylketonuria. Augmentation of hyperphenylalaninemia with alpha-methylphenylalanine and p-chlorophenylalanine.

Authors:  J D Lane; B Schöne; U Langenbeck; V Neuhoff
Journal:  Biochim Biophys Acta       Date:  1980-01-17
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  1 in total

1.  The effect of hyperphenylalaninaemia on the muscarinic acetylcholine receptor in the HPH-5 mouse brain.

Authors:  F A Hommes
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982
  1 in total

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