Literature DB >> 20501135

On a possible mechanism of abnormal brain development in experimental hyperphenylalaninemia.

F A Hommes1, K Matsuo.   

Abstract

It has been observed that high levels of phenylalanine inhibit the synthesis of sulfatides in brain. A possible scenario leading to a decreased number of synaptic contacts in the adult is developed as an explanation for brain dysfunction. The evidence for each of the steps of this scenario is reviewed.

Entities:  

Year:  1987        PMID： 20501135     DOI： 10.1016/0197-0186(87)90141-0

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  7 in total

1.  Effect of phenylalanine and p-chlorophenylalanine on Na+, K+-ATPase activity in the synaptic plasma membrane from the cerebral cortex of rats.

Authors:  E L Streck; P T Edom; M E Noriler; L F Borges; Z L Pontes; E Parolo; C S Dutra-Filho; C M Wannmacher; A T Wyse
Journal:  Metab Brain Dis       Date:  2000-06       Impact factor: 3.584

2.  Myelin turnover in hyperphenylalaninaemia. A re-evaluation with the HPH-5 mouse.

Authors:  F A Hommes; L Moss
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

3.  Magnetic resonance imaging of the brain in adolescents with phenylketonuria and in one case of 6-pyruvoyl tetrahydropteridine synthase deficiency.

Authors:  J Pietz; U K Meyding-Lamadé; H Schmidt
Journal:  Eur J Pediatr       Date:  1996-07       Impact factor: 3.183

4.  The effect of hyperphenylalaninaemia on the muscarinic acetylcholine receptor in the HPH-5 mouse brain.

Authors:  F A Hommes
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982

5.  Effect of phenylalanine and its metabolites on ATP diphosphohydrolase activity in synaptosomes from rat cerebral cortex.

Authors:  A T Wyse; J J Sarkis; J S Cunha-Filho; M V Teixeira; M R Schetinger; M Wajner; C Milton; D Wannmacher
Journal:  Neurochem Res       Date:  1994-09       Impact factor: 3.996

6.  The development of the muscarinic acetylcholine receptor in normal and hyperphenylalaninemic rat cerebrum.

Authors:  K Matsuo; F A Hommes
Journal:  Neurochem Res       Date:  1988-09       Impact factor: 3.996

Review 7.  White matter abnormalities in patients with treated hyperphenylalaninaemia: magnetic resonance relaxometry and proton spectroscopy findings.

Authors:  U Bick; K Ullrich; U Stöber; H Möller; G Schuierer; A C Ludolph; C Oberwittler; J Weglage; U Wendel
Journal:  Eur J Pediatr       Date:  1993-12       Impact factor: 3.183
  7 in total

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