Literature DB >> 32251391

A mountable toilet system for personalized health monitoring via the analysis of excreta.

Seung-Min Park1,2, Daeyoun D Won1,3,4, Brian J Lee1,2, Diego Escobedo1, Andre Esteva5, Amin Aalipour1,2, T Jessie Ge6, Jung Ha Kim3, Susie Suh7, Elliot H Choi7, Alexander X Lozano8,9, Chengyang Yao10, Sunil Bodapati11, Friso B Achterberg1,2,12, Jeesu Kim1,2,13, Hwan Park14, Youngjae Choi14, Woo Jin Kim14, Jung Ho Yu1,2, Alexander M Bhatt1, Jong Kyun Lee3,4, Ryan Spitler1,15, Shan X Wang8,10,16, Sanjiv S Gambhir17,18,19,20,21,22.   

Abstract

Technologies for the longitudinal monitoring of a person's health are poorly integrated with clinical workflows, and have rarely produced actionable biometric data for healthcare providers. Here, we describe easily deployable hardware and software for the long-term analysis of a user's excreta through data collection and models of human health. The 'smart' toilet, which is self-contained and operates autonomously by leveraging pressure and motion sensors, analyses the user's urine using a standard-of-care colorimetric assay that traces red-green-blue values from images of urinalysis strips, calculates the flow rate and volume of urine using computer vision as a uroflowmeter, and classifies stool according to the Bristol stool form scale using deep learning, with performance that is comparable to the performance of trained medical personnel. Each user of the toilet is identified through their fingerprint and the distinctive features of their anoderm, and the data are securely stored and analysed in an encrypted cloud server. The toilet may find uses in the screening, diagnosis and longitudinal monitoring of specific patient populations.

Entities:  

Mesh:

Year:  2020        PMID: 32251391      PMCID: PMC7377213          DOI: 10.1038/s41551-020-0534-9

Source DB:  PubMed          Journal:  Nat Biomed Eng        ISSN: 2157-846X            Impact factor:   25.671


  48 in total

1.  Small Molecule Detection in Saliva Facilitates Portable Tests of Marijuana Abuse.

Authors:  Jung-Rok Lee; Joohong Choi; Tyler O Shultz; Shan X Wang
Journal:  Anal Chem       Date:  2016-07-21       Impact factor: 6.986

2.  The precision medicine initiative: a new national effort.

Authors:  Euan A Ashley
Journal:  JAMA       Date:  2015-06-02       Impact factor: 56.272

3.  A new initiative on precision medicine.

Authors:  Francis S Collins; Harold Varmus
Journal:  N Engl J Med       Date:  2015-01-30       Impact factor: 91.245

4.  Precision medicine initiative.

Authors:  Demetrius J Porche
Journal:  Am J Mens Health       Date:  2015-03-10

Review 5.  Toward achieving precision health.

Authors:  Sanjiv Sam Gambhir; T Jessie Ge; Ophir Vermesh; Ryan Spitler
Journal:  Sci Transl Med       Date:  2018-02-28       Impact factor: 17.956

6.  Deactivated CRISPR Associated Protein 9 for Minor-Allele Enrichment in Cell-Free DNA.

Authors:  Amin Aalipour; Jonathan C Dudley; Seung-Min Park; Surya Murty; Jacob J Chabon; Evan A Boyle; Maximilian Diehn; Sanjiv S Gambhir
Journal:  Clin Chem       Date:  2017-10-16       Impact factor: 8.327

7.  Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors.

Authors:  G Peng; M Hakim; Y Y Broza; S Billan; R Abdah-Bortnyak; A Kuten; U Tisch; H Haick
Journal:  Br J Cancer       Date:  2010-07-20       Impact factor: 7.640

8.  Molecular profiling of single circulating tumor cells from lung cancer patients.

Authors:  Seung-Min Park; Dawson J Wong; Chin Chun Ooi; David M Kurtz; Ophir Vermesh; Amin Aalipour; Susie Suh; Kelsey L Pian; Jacob J Chabon; Sang Hun Lee; Mehran Jamali; Carmen Say; Justin N Carter; Luke P Lee; Ware G Kuschner; Erich J Schwartz; Joseph B Shrager; Joel W Neal; Heather A Wakelee; Maximilian Diehn; Viswam S Nair; Shan X Wang; Sanjiv S Gambhir
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-12       Impact factor: 11.205

9.  Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat.

Authors:  Amay J Bandodkar; Philipp Gutruf; Jungil Choi; KunHyuck Lee; Yurina Sekine; Jonathan T Reeder; William J Jeang; Alexander J Aranyosi; Stephen P Lee; Jeffrey B Model; Roozbeh Ghaffari; Chun-Ju Su; John P Leshock; Tyler Ray; Anthony Verrillo; Kyle Thomas; Vaishnavi Krishnamurthi; Seungyong Han; Jeonghyun Kim; Siddharth Krishnan; Tao Hang; John A Rogers
Journal:  Sci Adv       Date:  2019-01-18       Impact factor: 14.136

Review 10.  Detection of cancer through exhaled breath: a systematic review.

Authors:  Agne Krilaviciute; Jonathan Alexander Heiss; Marcis Leja; Juozas Kupcinskas; Hossam Haick; Hermann Brenner
Journal:  Oncotarget       Date:  2015-11-17
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  20 in total

Review 1.  Shifting machine learning for healthcare from development to deployment and from models to data.

Authors:  Angela Zhang; Lei Xing; James Zou; Joseph C Wu
Journal:  Nat Biomed Eng       Date:  2022-07-04       Impact factor: 25.671

2.  Artificial intelligence and inflammatory bowel disease: practicalities and future prospects.

Authors:  Johanne Brooks-Warburton; James Ashton; Anjan Dhar; Tony Tham; Patrick B Allen; Sami Hoque; Laurence B Lovat; Shaji Sebastian
Journal:  Frontline Gastroenterol       Date:  2021-12-10

Review 3.  The future of early cancer detection.

Authors:  Rebecca C Fitzgerald; Antonis C Antoniou; Ljiljana Fruk; Nitzan Rosenfeld
Journal:  Nat Med       Date:  2022-04-19       Impact factor: 87.241

Review 4.  Toilet-based continuous health monitoring using urine.

Authors:  Savas Tasoglu
Journal:  Nat Rev Urol       Date:  2022-01-21       Impact factor: 14.432

Review 5.  Clinical Features of Parkinson's Disease: The Evolution of Critical Symptoms.

Authors:  Csaba Váradi
Journal:  Biology (Basel)       Date:  2020-05-19

6.  Can a toilet promote virus transmission? From a fluid dynamics perspective.

Authors:  Yun-Yun Li; Ji-Xiang Wang; Xi Chen
Journal:  Phys Fluids (1994)       Date:  2020-06-01       Impact factor: 3.521

7.  Design and evaluation of a novel approach to invisible electrocardiography (ECG) in sanitary facilities using polymeric electrodes.

Authors:  Aline Dos Santos Silva; Hugo Almeida; Hugo Plácido da Silva; António Oliveira
Journal:  Sci Rep       Date:  2021-03-18       Impact factor: 4.379

Review 8.  Deep learning-enabled medical computer vision.

Authors:  Andre Esteva; Katherine Chou; Serena Yeung; Nikhil Naik; Ali Madani; Ali Mottaghi; Yun Liu; Eric Topol; Jeff Dean; Richard Socher
Journal:  NPJ Digit Med       Date:  2021-01-08

9.  Mobile sonouroflowmetry using voiding sound and volume.

Authors:  Elie El Helou; Joy Naba; Karim Youssef; Georges Mjaess; Ghassan Sleilaty; Samar Helou
Journal:  Sci Rep       Date:  2021-05-27       Impact factor: 4.379

10.  Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults.

Authors:  Daiki Watanabe; Haruka Murakami; Harumi Ohno; Kumpei Tanisawa; Kana Konishi; Kikue Todoroki-Mori; Yuta Tsunematsu; Michio Sato; Yuji Ogata; Noriyuki Miyoshi; Naoto Kubota; Jun Kunisawa; Keiji Wakabayashi; Tetsuya Kubota; Kenji Watanabe; Motohiko Miyachi
Journal:  BMC Microbiol       Date:  2021-06-28       Impact factor: 3.605

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