Blood biomarkers of herbicide, insecticide, and fungicide toxicity to fish-a review.

Pesticides are widely used in the world agriculture, and they may adversely affect non-target organisms, including fish. The present 2000-2019 literature review summarizes hematological and blood biochemical effects of various herbicides, insecticides, and fungicides in fish. The observed changes usually indicate anemia and inflammation, as well as hyperglycemia, hypoproteinemia, increase in cortisol concentration and activities of hepatic aminotransferases that are typical for intoxication and stress. Other changes that are also sometimes observed such as increase in red blood parameters indicate compensatory response. The often-noted symptoms of immunosuppression show an adverse effect of pesticides on immune system and possible immunosuppression. Pathophysiological changes in fish induced by pesticides depend on many factors, such as active compound and its concentration, exposure duration, fish species, environmental conditions, etc. Hematological and blood biochemical parameters appear to be useful biomarkers for evaluation of physiological state of fish exposed to pesticides; however, they are not specific markers of intoxication.