Effects of Dietary Bovine Lactoferrin on Growth Performance and Immuno-physiological Responses of Asian Sea Bass (Lates calcarifer) Fingerlings.

The aim of this study was to evaluate the effects of lactoferrin (Lf) on growth and feeding performance, biochemical and immune parameters in Asian sea bass (Lates calcarifer). A basal diet was supplemented with 0 (control), 400 (400 Lf), or 800 (800 Lf) mg Lf kg-1 diet. The results indicate a significant increase in innate immune parameters when the diet was supplemented with 800 mg Lf kg-1. The highest serum albumin value and the lowest serum glucose concentration were observed in 800 Lf group. The liver catalase activity in the 400 Lf and 800 Lf groups was lower than the control value. Moreover, malondialdehyde concentration in the liver of Asian sea bass was increased with increasing the dietary Lf supplementation. The results of the study suggest that supplementing diet with 800 mg Lf kg-1 stimulates non-specific immune response in Asian sea bass. Nonetheless, selecting an appropriate dose can be difficult, especially since both the higher and the lower dose tested may result in adverse effects.