Literature DB >> 32227657

dbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions.

Chang Li1, Chengcheng Mou2, Michael D Swartz3, Bing Yu4, Yongsheng Bai5, Yicheng Tu2, Xiaoming Liu1.   

Abstract

MicroRNAs (miRNA) are short noncoding RNAs that can repress the expression of protein-coding messenger RNAs (mRNAs) by binding to the 3'-untranslated region (UTR) of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3'-UTR of the mRNAs can disrupt miRNA regulation. In this study, we presented dbMTS, a database for miRNA target site (MTS) SNVs and their functional annotations. This database can help studies easily identify putative SNVs that affect miRNA targeting and facilitate the prioritization of their functional importance. dbMTS is freely available for academic use at http://database.liulab.science/dbMTS as a web service or a downloadable attached database of dbNSFP.
© 2020 Wiley Periodicals, Inc.

Entities:  

Keywords:  3′-untranslated region; database; functional prediction; microRNA target; variant

Year:  2020        PMID： 32227657      PMCID： PMC7251985          DOI： 10.1002/humu.24020

Source DB:  PubMed          Journal:  Hum Mutat        ISSN： 1059-7794            Impact factor:   4.878


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