Literature DB >> 322152

Effects of naloxone on experimentally induced ischemic pain and on mood in human subjects.

P Grevert, A Goldstein.   

Abstract

The hypothesis that painful stimuli activate the endogenous opioid (endorphin) system in humans was tested by examining the effect of the opiate antagonist naloxone on experimentally induced ischemic pain and on subjective mood ratings. Intravenous injections of saline or naloxone hydrochloride (2 and 10 mg) were administered under double-blind conditions to 12 subjects. Naloxone did not affect the pain ratings. However, a significant dose-related effect of naloxone on tension-anxiety was found, suggesting that the endorphins. like exogenously administered opiates, may have antianxiety properties.

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Year:  1977        PMID： 322152      PMCID： PMC430670          DOI： 10.1073/pnas.74.3.1291

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties.

Authors:  B M Cox; K E Opheim; H Teschemacher; A Goldstein
Journal:  Life Sci       Date:  1975-06-15       Impact factor: 5.037

2.  On the role of endogenous opioid peptides: failure of naloxone to influence shock escape threshold in the rat.

Authors:  A Goldstein; G T Pryor; L S Otis; F Larsen
Journal:  Life Sci       Date:  1976-03-15       Impact factor: 5.037

3.  Lack of effect of naloxone on pain perception in humans.

Authors:  A El-Sobky; J O Dostrovsky; P D Wall
Journal:  Nature       Date:  1976-10-28       Impact factor: 49.962

4.  Opioid peptides endorphins in pituitary and brain.

Authors:  A Goldstein
Journal:  Science       Date:  1976-09-17       Impact factor: 47.728

5.  [Enhancement of nociceptive reactions by naloxone in mice and rats (author's transl)].

Authors:  J J Jacob; E C Tremblay; M C Colombel
Journal:  Psychopharmacologia       Date:  1974-07-11

6.  Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist.

Authors:  H Akil; D J Mayer; J C Liebeskind
Journal:  Science       Date:  1976-03-05       Impact factor: 47.728

7.  Naltrexone: physiological and psychological effects of single doses.

Authors:  E R Gritz; S M Shiffman; M E Jarvik; J Schlesinger; V C Charuvastra
Journal:  Clin Pharmacol Ther       Date:  1976-06       Impact factor: 6.875

8.  Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Authors:  J Hughes; T W Smith; H W Kosterlitz; L A Fothergill; B A Morgan; H R Morris
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962

9.  Studies of EN-1639A (naltrexone): a new narcotic antagonist.

Authors:  R B Resnick; J Volavka; A M Freedman; M Thomas
Journal:  Am J Psychiatry       Date:  1974-06       Impact factor: 18.112

10.  Naloxone reversal of analgesia produced by brain stimulation in the human.

Authors:  J E Adams
Journal:  Pain       Date:  1976-06       Impact factor: 6.961
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  28 in total

1.  Aversive property of opioid receptor blockade in drug-naive mice.

Authors:  R F Mucha; M J Walker
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 2.  Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems.

Authors:  Alan R Gintzler; Nai-Jiang Liu
Journal:  Transl Res       Date:  2021-02-07       Impact factor: 7.012

Review 3.  The role of opioid processes in reward and decision-making.

Authors:  Vincent Laurent; Ashleigh K Morse; Bernard W Balleine
Journal:  Br J Pharmacol       Date:  2015-01       Impact factor: 8.739

4.  Effects of aspirin, naloxone and placebo.

Authors:  A A Mewa; D Rosenbloom; E M Grace; P Brooks; N Bellamy; C Denko; G Norman; W W Buchanan
Journal:  Clin Rheumatol       Date:  1987-12       Impact factor: 2.980

5.  The effects of naloxone on opiate and placebo analgesia in healthy volunteers.

Authors:  J Posner; C A Burke
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

6.  Nociceptive flexion reflex and pain rating responses during endogenous opiate blockade with naltrexone in healthy young adults.

Authors:  Christopher R France; Mustafa al'Absi; Christopher Ring; Janis L France; Angie Harju; Lorentz E Wittmers
Journal:  Biol Psychol       Date:  2006-12-27       Impact factor: 3.251

7.  Opioid antagonists and the sexual satiation phenomenon.

Authors:  G Rodríguez-Manzo; A Fernández-Guasti
Journal:  Psychopharmacology (Berl)       Date:  1995-11       Impact factor: 4.530

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Authors:  C Xenakis; W Holtmann
Journal:  Arch Psychiatr Nervenkr (1970)       Date:  1979-07-04

9.  Naloxone fails to reverse hypnotic alleviation of chronic pain.

Authors:  D Spiegel; L H Albert
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

10.  Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems.

Authors:  M Amanzio; F Benedetti
Journal:  J Neurosci       Date:  1999-01-01       Impact factor: 6.167
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