BACKGROUND: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. PROCEDURES: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. RESULTS: Regorafenib induced modest inhibition of tumor growth in the models evaluated. CONCLUSION: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.
BACKGROUND: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. PROCEDURES: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. RESULTS: Regorafenib induced modest inhibition of tumor growth in the models evaluated. CONCLUSION: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.
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Authors: Holcombe E Grier; Mark D Krailo; Nancy J Tarbell; Michael P Link; Christopher J H Fryer; Douglas J Pritchard; Mark C Gebhardt; Paul S Dickman; Elizabeth J Perlman; Paul A Meyers; Sarah S Donaldson; Sheila Moore; Aaron R Rausen; Teresa J Vietti; James S Miser Journal: N Engl J Med Date: 2003-02-20 Impact factor: 91.245
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Authors: Geoffrey Neale; Xiaoping Su; Christopher L Morton; Doris Phelps; Richard Gorlick; Richard B Lock; C Patrick Reynolds; John M Maris; Henry S Friedman; Jeffrey Dome; Joseph Khoury; Timothy J Triche; Robert C Seeger; Richard Gilbertson; Javed Khan; Malcolm A Smith; Peter J Houghton Journal: Clin Cancer Res Date: 2008-07-15 Impact factor: 12.531
Authors: George D Demetri; Peter Reichardt; Yoon-Koo Kang; Jean-Yves Blay; Piotr Rutkowski; Hans Gelderblom; Peter Hohenberger; Michael Leahy; Margaret von Mehren; Heikki Joensuu; Giuseppe Badalamenti; Martin Blackstein; Axel Le Cesne; Patrick Schöffski; Robert G Maki; Sebastian Bauer; Binh Bui Nguyen; Jianming Xu; Toshirou Nishida; John Chung; Christian Kappeler; Iris Kuss; Dirk Laurent; Paolo G Casali Journal: Lancet Date: 2012-11-22 Impact factor: 79.321
Authors: Brenda J Weigel; Elizabeth Lyden; James R Anderson; William H Meyer; David M Parham; David A Rodeberg; Jeff M Michalski; Douglas S Hawkins; Carola A S Arndt Journal: J Clin Oncol Date: 2015-10-26 Impact factor: 44.544
Authors: Jo Lynne Rokita; Komal S Rathi; Maria F Cardenas; Kristen A Upton; Joy Jayaseelan; Katherine L Cross; Jacob Pfeil; Laura E Egolf; Gregory P Way; Alvin Farrel; Nathan M Kendsersky; Khushbu Patel; Krutika S Gaonkar; Apexa Modi; Esther R Berko; Gonzalo Lopez; Zalman Vaksman; Chelsea Mayoh; Jonas Nance; Kristyn McCoy; Michelle Haber; Kathryn Evans; Hannah McCalmont; Katerina Bendak; Julia W Böhm; Glenn M Marshall; Vanessa Tyrrell; Karthik Kalletla; Frank K Braun; Lin Qi; Yunchen Du; Huiyuan Zhang; Holly B Lindsay; Sibo Zhao; Jack Shu; Patricia Baxter; Christopher Morton; Dias Kurmashev; Siyuan Zheng; Yidong Chen; Jay Bowen; Anthony C Bryan; Kristen M Leraas; Sara E Coppens; HarshaVardhan Doddapaneni; Zeineen Momin; Wendong Zhang; Gregory I Sacks; Lori S Hart; Kateryna Krytska; Yael P Mosse; Gregory J Gatto; Yolanda Sanchez; Casey S Greene; Sharon J Diskin; Olena Morozova Vaske; David Haussler; Julie M Gastier-Foster; E Anders Kolb; Richard Gorlick; Xiao-Nan Li; C Patrick Reynolds; Raushan T Kurmasheva; Peter J Houghton; Malcolm A Smith; Richard B Lock; Pichai Raman; David A Wheeler; John M Maris Journal: Cell Rep Date: 2019-11-05 Impact factor: 9.423