| Literature DB >> 32198502 |
Jean Shin1,2, Shaojie Ma3,4, Edith Hofer5,6, Yash Patel2, Daniel E Vosberg2, Steven Tilley2, Gennady V Roshchupkin7,8,9, André M M Sousa10, Xueqiu Jian11, Rebecca Gottesman12, Thomas H Mosley13, Myriam Fornage11, Yasaman Saba14, Lukas Pirpamer5, Reinhold Schmidt5, Helena Schmidt14, Amaia Carrion-Castillo15, Fabrice Crivello16, Bernard Mazoyer16, Joshua C Bis17, Shuo Li18, Qiong Yang18, Michelle Luciano19,20, Sherif Karama21, Lindsay Lewis21, Mark E Bastin19,22, Mathew A Harris22,23, Joanna M Wardlaw19,24, Ian E Deary19,20, Markus Scholz25,26, Markus Loeffler25,26, A Veronica Witte27,28,29, Frauke Beyer27,28, Arno Villringer27,28,29, Nicola J Armstrong30, Karen A Mather31,32, David Ames33,34, Jiyang Jiang31, John B Kwok35,36, Peter R Schofield32,36, Anbupalam Thalamuthu31, Julian N Trollor31,37, Margaret J Wright38,39, Henry Brodaty31,40, Wei Wen31, Perminder S Sachdev31,41, Natalie Terzikhan9, Tavia E Evans7,9, Hieab H H H Adams7,9, M Arfan Ikram7,9,42, Stefan Frenzel43, Sandra van der Auwera-Palitschka43,44, Katharina Wittfeld43,44, Robin Bülow45, Hans Jörgen Grabe43,44, Christophe Tzourio46,47, Aniket Mishra46, Sophie Maingault48, Stephanie Debette46,47,49, Nathan A Gillespie50, Carol E Franz51,52, William S Kremen51,52,53, Linda Ding54, Neda Jahanshad54, Nenad Sestan3,4, Zdenka Pausova1,55,56, Sudha Seshadri49,57, Tomas Paus2,58,59.
Abstract
We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.Entities:
Keywords: brain development; cortical surface area; cortical thickness; genome-wide association study; occupational aptitude
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Year: 2020 PMID： 32198502 PMCID： PMC7947185 DOI： 10.1093/cercor/bhaa035
Source DB: PubMed Journal: Cereb Cortex ISSN： 1047-3211 Impact factor: 5.357