BACKGROUND: The primary aim of genome-wide association studies is to identify novel genetic loci associated with interindividual variation in the levels of risk factors, the degree of subclinical disease, or the risk of clinical disease. The requirement for large sample sizes and the importance of replication have served as powerful incentives for scientific collaboration. Methods- The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium was formed to facilitate genome-wide association studies meta-analyses and replication opportunities among multiple large population-based cohort studies, which collect data in a standardized fashion and represent the preferred method for estimating disease incidence. The design of the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium includes 5 prospective cohort studies from the United States and Europe: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study. With genome-wide data on a total of about 38 000 individuals, these cohort studies have a large number of health-related phenotypes measured in similar ways. For each harmonized trait, within-cohort genome-wide association study analyses are combined by meta-analysis. A prospective meta-analysis of data from all 5 cohorts, with a properly selected level of genome-wide statistical significance, is a powerful approach to finding genuine phenotypic associations with novel genetic loci. CONCLUSIONS: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium and collaborating non-member studies or consortia provide an excellent framework for the identification of the genetic determinants of risk factors, subclinical-disease measures, and clinical events.
BACKGROUND: The primary aim of genome-wide association studies is to identify novel genetic loci associated with interindividual variation in the levels of risk factors, the degree of subclinical disease, or the risk of clinical disease. The requirement for large sample sizes and the importance of replication have served as powerful incentives for scientific collaboration. Methods- The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium was formed to facilitate genome-wide association studies meta-analyses and replication opportunities among multiple large population-based cohort studies, which collect data in a standardized fashion and represent the preferred method for estimating disease incidence. The design of the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium includes 5 prospective cohort studies from the United States and Europe: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study. With genome-wide data on a total of about 38 000 individuals, these cohort studies have a large number of health-related phenotypes measured in similar ways. For each harmonized trait, within-cohort genome-wide association study analyses are combined by meta-analysis. A prospective meta-analysis of data from all 5 cohorts, with a properly selected level of genome-wide statistical significance, is a powerful approach to finding genuine phenotypic associations with novel genetic loci. CONCLUSIONS: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium and collaborating non-member studies or consortia provide an excellent framework for the identification of the genetic determinants of risk factors, subclinical-disease measures, and clinical events.
Authors: Anna Helgadottir; Gudmar Thorleifsson; Andrei Manolescu; Solveig Gretarsdottir; Thorarinn Blondal; Aslaug Jonasdottir; Adalbjorg Jonasdottir; Asgeir Sigurdsson; Adam Baker; Arnar Palsson; Gisli Masson; Daniel F Gudbjartsson; Kristinn P Magnusson; Karl Andersen; Allan I Levey; Valgerdur M Backman; Sigurborg Matthiasdottir; Thorbjorg Jonsdottir; Stefan Palsson; Helga Einarsdottir; Steinunn Gunnarsdottir; Arnaldur Gylfason; Viola Vaccarino; W Craig Hooper; Muredach P Reilly; Christopher B Granger; Harland Austin; Daniel J Rader; Svati H Shah; Arshed A Quyyumi; Jeffrey R Gulcher; Gudmundur Thorgeirsson; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson Journal: Science Date: 2007-05-03 Impact factor: 47.728
Authors: Mark I McCarthy; Gonçalo R Abecasis; Lon R Cardon; David B Goldstein; Julian Little; John P A Ioannidis; Joel N Hirschhorn Journal: Nat Rev Genet Date: 2008-05 Impact factor: 53.242
Authors: L P Fried; N O Borhani; P Enright; C D Furberg; J M Gardin; R A Kronmal; L H Kuller; T A Manolio; M B Mittelmark; A Newman Journal: Ann Epidemiol Date: 1991-02 Impact factor: 3.797
Authors: John P A Ioannidis; Paolo Boffetta; Julian Little; Thomas R O'Brien; Andre G Uitterlinden; Paolo Vineis; David J Balding; Anand Chokkalingam; Siobhan M Dolan; W Dana Flanders; Julian P T Higgins; Mark I McCarthy; David H McDermott; Grier P Page; Timothy R Rebbeck; Daniela Seminara; Muin J Khoury Journal: Int J Epidemiol Date: 2007-09-26 Impact factor: 7.196
Authors: Albert Hofman; Monique M B Breteler; Cornelia M van Duijn; Gabriel P Krestin; Huibert A Pols; Bruno H Ch Stricker; Henning Tiemeier; André G Uitterlinden; Johannes R Vingerling; Jacqueline C M Witteman Journal: Eur J Epidemiol Date: 2007-10-23 Impact factor: 8.082
Authors: Eleftheria Zeggini; Laura J Scott; Richa Saxena; Benjamin F Voight; Jonathan L Marchini; Tianle Hu; Paul I W de Bakker; Gonçalo R Abecasis; Peter Almgren; Gitte Andersen; Kristin Ardlie; Kristina Bengtsson Boström; Richard N Bergman; Lori L Bonnycastle; Knut Borch-Johnsen; Noël P Burtt; Hong Chen; Peter S Chines; Mark J Daly; Parimal Deodhar; Chia-Jen Ding; Alex S F Doney; William L Duren; Katherine S Elliott; Michael R Erdos; Timothy M Frayling; Rachel M Freathy; Lauren Gianniny; Harald Grallert; Niels Grarup; Christopher J Groves; Candace Guiducci; Torben Hansen; Christian Herder; Graham A Hitman; Thomas E Hughes; Bo Isomaa; Anne U Jackson; Torben Jørgensen; Augustine Kong; Kari Kubalanza; Finny G Kuruvilla; Johanna Kuusisto; Claudia Langenberg; Hana Lango; Torsten Lauritzen; Yun Li; Cecilia M Lindgren; Valeriya Lyssenko; Amanda F Marvelle; Christa Meisinger; Kristian Midthjell; Karen L Mohlke; Mario A Morken; Andrew D Morris; Narisu Narisu; Peter Nilsson; Katharine R Owen; Colin N A Palmer; Felicity Payne; John R B Perry; Elin Pettersen; Carl Platou; Inga Prokopenko; Lu Qi; Li Qin; Nigel W Rayner; Matthew Rees; Jeffrey J Roix; Anelli Sandbaek; Beverley Shields; Marketa Sjögren; Valgerdur Steinthorsdottir; Heather M Stringham; Amy J Swift; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Nicholas J Timpson; Tiinamaija Tuomi; Jaakko Tuomilehto; Mark Walker; Richard M Watanabe; Michael N Weedon; Cristen J Willer; Thomas Illig; Kristian Hveem; Frank B Hu; Markku Laakso; Kari Stefansson; Oluf Pedersen; Nicholas J Wareham; Inês Barroso; Andrew T Hattersley; Francis S Collins; Leif Groop; Mark I McCarthy; Michael Boehnke; David Altshuler Journal: Nat Genet Date: 2008-03-30 Impact factor: 38.330
Authors: Yelena Bykhovskaya; Xiaohui Li; Irina Epifantseva; Talin Haritunians; David Siscovick; Anthony Aldave; Loretta Szczotka-Flynn; Sudha K Iyengar; Kent D Taylor; Jerome I Rotter; Yaron S Rabinowitz Journal: Invest Ophthalmol Vis Sci Date: 2012-06-28 Impact factor: 4.799
Authors: Michael Preuss; Inke R König; John R Thompson; Jeanette Erdmann; Devin Absher; Themistocles L Assimes; Stefan Blankenberg; Eric Boerwinkle; Li Chen; L Adrienne Cupples; Alistair S Hall; Eran Halperin; Christian Hengstenberg; Hilma Holm; Reijo Laaksonen; Mingyao Li; Winfried März; Ruth McPherson; Kiran Musunuru; Christopher P Nelson; Mary Susan Burnett; Stephen E Epstein; Christopher J O'Donnell; Thomas Quertermous; Daniel J Rader; Robert Roberts; Arne Schillert; Kari Stefansson; Alexandre F R Stewart; Gudmar Thorleifsson; Benjamin F Voight; George A Wells; Andreas Ziegler; Sekar Kathiresan; Muredach P Reilly; Nilesh J Samani; Heribert Schunkert Journal: Circ Cardiovasc Genet Date: 2010-10-05
Authors: Christopher J O'Donnell; Maryam Kavousi; Albert V Smith; Sharon L R Kardia; Mary F Feitosa; Shih-Jen Hwang; Yan V Sun; Michael A Province; Thor Aspelund; Abbas Dehghan; Udo Hoffmann; Lawrence F Bielak; Qunyuan Zhang; Gudny Eiriksdottir; Cornelia M van Duijn; Caroline S Fox; Mariza de Andrade; Aldi T Kraja; Sigurdur Sigurdsson; Suzette E Elias-Smale; Joanne M Murabito; Lenore J Launer; Aad van der Lugt; Sekar Kathiresan; Gabriel P Krestin; David M Herrington; Timothy D Howard; Yongmei Liu; Wendy Post; Braxton D Mitchell; Jeffrey R O'Connell; Haiqing Shen; Alan R Shuldiner; David Altshuler; Roberto Elosua; Veikko Salomaa; Stephen M Schwartz; David S Siscovick; Benjamin F Voight; Joshua C Bis; Nicole L Glazer; Bruce M Psaty; Eric Boerwinkle; Gerardo Heiss; Stefan Blankenberg; Tanja Zeller; Philipp S Wild; Renate B Schnabel; Arne Schillert; Andreas Ziegler; Thomas F Münzel; Charles C White; Jerome I Rotter; Michael Nalls; Matthijs Oudkerk; Andrew D Johnson; Anne B Newman; Andre G Uitterlinden; Joseph M Massaro; Julie Cunningham; Tamara B Harris; Albert Hofman; Patricia A Peyser; Ingrid B Borecki; L Adrienne Cupples; Vilmundur Gudnason; Jacqueline C M Witteman Journal: Circulation Date: 2011-12-05 Impact factor: 29.690
Authors: Stefan Walter; Johan Mackenbach; Zoltán Vokó; Stefan Lhachimi; M Arfan Ikram; André G Uitterlinden; Anne B Newman; Joanne M Murabito; Melissa E Garcia; Vilmundur Gudnason; Toshiko Tanaka; Gregory J Tranah; Henri Wallaschofski; Thomas Kocher; Lenore J Launer; Nora Franceschini; Maarten Schipper; Albert Hofman; Henning Tiemeier Journal: Am J Public Health Date: 2012-02-16 Impact factor: 9.308
Authors: Jonathan P Beauchamp; David Cesarini; Magnus Johannesson; Matthijs J H M van der Loos; Philipp D Koellinger; Patrick J F Groenen; James H Fowler; J Niels Rosenquist; A Roy Thurik; Nicholas A Christakis Journal: J Econ Perspect Date: 2011
Authors: Xiaohui Li; Yelena Bykhovskaya; Talin Haritunians; David Siscovick; Anthony Aldave; Loretta Szczotka-Flynn; Sudha K Iyengar; Jerome I Rotter; Kent D Taylor; Yaron S Rabinowitz Journal: Hum Mol Genet Date: 2011-10-06 Impact factor: 6.150
Authors: Weihong Tang; Saonli Basu; Xiaoxiao Kong; James S Pankow; Nena Aleksic; Adrian Tan; Mary Cushman; Eric Boerwinkle; Aaron R Folsom Journal: Blood Date: 2010-08-27 Impact factor: 22.113
Authors: Vincenzo Macri; Jennifer A Brody; Dan E Arking; William J Hucker; Xiaoyan Yin; Honghuang Lin; Robert W Mills; Moritz F Sinner; Steven A Lubitz; Ching-Ti Liu; Alanna C Morrison; Alvaro Alonso; Ning Li; Vadim V Fedorov; Paul M Janssen; Joshua C Bis; Susan R Heckbert; Elena V Dolmatova; Thomas Lumley; Colleen M Sitlani; L Adrienne Cupples; Sara L Pulit; Christopher Newton-Cheh; John Barnard; Jonathan D Smith; David R Van Wagoner; Mina K Chung; Gus J Vlahakes; Christopher J O'Donnell; Jerome I Rotter; Kenneth B Margulies; Michael P Morley; Thomas P Cappola; Emelia J Benjamin; Donna Muzny; Richard A Gibbs; Rebecca D Jackson; Jared W Magnani; Caroline N Herndon; Stephen S Rich; Bruce M Psaty; David J Milan; Eric Boerwinkle; Peter J Mohler; Nona Sotoodehnia; Patrick T Ellinor Journal: Circ Genom Precis Med Date: 2018-05
Authors: Carla A Ibrahim-Verbaas; Myriam Fornage; Joshua C Bis; Seung Hoan Choi; Bruce M Psaty; James B Meigs; Madhu Rao; Mike Nalls; Joao D Fontes; Christopher J O'Donnell; Sekar Kathiresan; Georg B Ehret; Caroline S Fox; Rainer Malik; Martin Dichgans; Helena Schmidt; Jari Lahti; Susan R Heckbert; Thomas Lumley; Kenneth Rice; Jerome I Rotter; Kent D Taylor; Aaron R Folsom; Eric Boerwinkle; Wayne D Rosamond; Eyal Shahar; Rebecca F Gottesman; Peter J Koudstaal; Najaf Amin; Renske G Wieberdink; Abbas Dehghan; Albert Hofman; André G Uitterlinden; Anita L Destefano; Stephanie Debette; Luting Xue; Alexa Beiser; Philip A Wolf; Charles Decarli; M Arfan Ikram; Sudha Seshadri; Thomas H Mosley; W T Longstreth; Cornelia M van Duijn; Lenore J Launer Journal: Stroke Date: 2014-01-16 Impact factor: 7.914