Literature DB >> 3219476

A 5-HT1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurones in vitro.

N R Newberry1, T Priestley.   

Abstract

5-Hydroxytryptamine (5-HT), 5-carboxamidotryptamine and 8-hydroxy-2-(di-n-propylamino)-tetralin inhibited rat ventromedial hypothalamic neurones in vitro in a concentration-dependent manner. The agonist-induced inhibition was reduced by spiperone (1 microM) and by pertussis toxin , but not by MDL 72222 (10 microM) or ketanserin (1 microM). The inhibition appeared to be mediated via 5-HT1A-receptors and a pertussis toxin-sensitive pathway.

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Year:  1988        PMID： 3219476      PMCID： PMC1854147          DOI： 10.1111/j.1476-5381.1988.tb16541.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Origin of serotonin innervation of the arcuate and ventromedial hypothalamic region.

Authors:  J O Willoughby; W W Blessing
Journal:  Brain Res       Date:  1987-08-18       Impact factor: 3.252

2.  Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine.

Authors:  P B Bradley; G Engel; W Feniuk; J R Fozard; P P Humphrey; D N Middlemiss; E J Mylecharane; B P Richardson; P R Saxena
Journal:  Neuropharmacology       Date:  1986-06       Impact factor: 5.250

3.  A 5-HT1-like receptor mediates a sympathetic ganglionic hyperpolarization.

Authors:  M J Gilbert; N R Newberry
Journal:  Eur J Pharmacol       Date:  1987-12-15       Impact factor: 4.432

4.  8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.

Authors:  D N Middlemiss; J R Fozard
Journal:  Eur J Pharmacol       Date:  1983-05-20       Impact factor: 4.432

5.  Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

Authors:  P C Sternweis; J D Robishaw
Journal:  J Biol Chem       Date:  1984-11-25       Impact factor: 5.157

6.  Hyperphagia and obesity in rats with bilateral ibotenic acid-induced lesions of the ventromedial hypothalamic nucleus.

Authors:  N Shimizu; Y Oomura; C R Plata-Salamán; M Morimoto
Journal:  Brain Res       Date:  1987-07-21       Impact factor: 3.252

Review 7.  Is there a role for serotonin (5-hydroxytryptamine) in feeding?

Authors:  J E Blundell
Journal:  Int J Obes       Date:  1977

8.  Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin.

Authors:  D Hoyer; G Engel; H O Kalkman
Journal:  Eur J Pharmacol       Date:  1985-11-26       Impact factor: 4.432

9.  A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.

Authors:  R Andrade; R C Malenka; R A Nicoll
Journal:  Science       Date:  1986-12-05       Impact factor: 47.728

10.  Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats.

Authors:  D Vergé; G Daval; M Marcinkiewicz; A Patey; S el Mestikawy; H Gozlan; M Hamon
Journal:  J Neurosci       Date:  1986-12       Impact factor: 6.167
  10 in total

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