Literature DB >> 2964375

A 5-HT1-like receptor mediates a sympathetic ganglionic hyperpolarization.

M J Gilbert1, N R Newberry.   

Abstract

5-HT induced a hyperpolarization of the rat superior cervical ganglion in vitro which was resistant to both MDL 72222 (10 microM), a 5-HT3 antagonist, and ketanserin (1 microM), a 5-HT2 antagonist. The 5-HT1-selective ligands 5-carboxamidotryptamine and 8-OH-DPAT also hyperpolarized the ganglion. The 5-HT-induced hyperpolarization was potently antagonised by spiperone. These results suggest that 5-HT hyperpolarizes the rat superior cervical ganglion via a 5-HT1-like receptor which resembles the central 5-HT1A binding site.

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Year:  1987        PMID： 2964375     DOI： 10.1016/0014-2999(87)90393-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

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Authors:  C J Watkins; N R Newberry
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

3.  The antagonist actions of WAY-100135 and its enantiomers on 5-HT1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion.

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4.  A 5-HT1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurones in vitro.

Authors:  N R Newberry; T Priestley
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739
  4 in total

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