Literature DB >> 3476178

Hyperphagia and obesity in rats with bilateral ibotenic acid-induced lesions of the ventromedial hypothalamic nucleus.

N Shimizu, Y Oomura, C R Plata-Salamán, M Morimoto.   

Abstract

Macro-electrophoretic applications of the cellular neurotoxin ibotenic acid into the ventromedial hypothalamic nucleus (VMH) resulted in hyperphagia and obesity in male rats. Histological examination showed a reduction in the number of neuronal VMH cell bodies with glial proliferation without evidence of non-specific damage. This supports the hypothesis that hyperphagia and obesity after VMH lesions are related to destruction of neurons intrinsic to the VMH.

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Year:  1987        PMID： 3476178     DOI： 10.1016/0006-8993(87)91508-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  14 in total

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