| Literature DB >> 27548312 |
Shane McCarthy1, Sayantan Das2,3, Warren Kretzschmar4, Olivier Delaneau5, Andrew R Wood6, Alexander Teumer7,8, Hyun Min Kang2,3, Christian Fuchsberger2,3, Petr Danecek9, Kevin Sharp10, Yang Luo1, Carlo Sidore11, Alan Kwong2,3, Nicholas Timpson12, Seppo Koskinen13, Scott Vrieze14,15, Laura J Scott2,3, He Zhang16, Anubha Mahajan4, Jan Veldink17, Ulrike Peters18,19, Carlos Pato20, Cornelia M van Duijn21, Christopher E Gillies22, Ilaria Gandin23, Massimo Mezzavilla24,25, Arthur Gilly1, Massimiliano Cocca23, Michela Traglia26, Andrea Angius11, Jeffrey C Barrett1, Dorrett Boomsma27, Kari Branham28, Gerome Breen29,30, Chad M Brummett31, Fabio Busonero11, Harry Campbell32, Andrew Chan32,33, Sai Chen2,3,34,35, Emily Chew36, Francis S Collins37, Laura J Corbin12, George Davey Smith12, George Dedoussis38, Marcus Dorr39,40, Aliki-Eleni Farmaki38, Luigi Ferrucci41, Lukas Forer42, Ross M Fraser31, Stacey Gabriel43, Shawn Levy44, Leif Groop45,46,47, Tabitha Harrison18, Andrew Hattersley48, Oddgeir L Holmen49, Kristian Hveem49, Matthias Kretzler34,35,50, James C Lee51,52, Matt McGue53, Thomas Meitinger54,55,56, David Melzer57, Josine L Min12, Karen L Mohlke58, John B Vincent59,60,61, Matthias Nauck8,40, Deborah Nickerson62, Aarno Palotie43,63,64,65,66,67, Michele Pato20, Nicola Pirastu23, Melvin McInnis68, J Brent Richards69,70,71, Cinzia Sala26, Veikko Salomaa13, David Schlessinger72, Sebastian Schoenherr42, P Eline Slagboom73, Kerrin Small71, Timothy Spector71, Dwight Stambolian74, Marcus Tuke6, Jaakko Tuomilehto75,76,77,78, Leonard H Van den Berg17, Wouter Van Rheenen17, Uwe Volker40,79, Cisca Wijmenga80, Daniela Toniolo26, Eleftheria Zeggini1, Paolo Gasparini23,25, Matthew G Sampson22, James F Wilson32,81, Timothy Frayling6, Paul I W de Bakker82,83, Morris A Swertz80,84, Steven McCarroll85,86, Charles Kooperberg18, Annelot Dekker17, David Altshuler43,65,87,88,89,90, Cristen Willer16,34,35, William Iacono53, Samuli Ripatti91, Nicole Soranzo1,92,93, Klaudia Walter1, Anand Swaroop94, Francesco Cucca11, Carl A Anderson1, Richard M Myers44, Michael Boehnke2,3, Mark I McCarthy4,95,96, Richard Durbin1.
Abstract
We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.Entities:
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Year: 2016 PMID： 27548312 PMCID： PMC5388176 DOI： 10.1038/ng.3643
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330