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Literature DB >> 32179913

Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?

Alexis Diaz-Vegas^1,2, Pablo Sanchez-Aguilera¹, James R Krycer², Pablo E Morales¹, Matías Monsalves-Alvarez^1,3, Mariana Cifuentes^1,3,4, Beverly A Rothermel⁵, Sergio Lavandero^1,5,4.

Abstract

Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction, and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the preclinical evidence associated with the regulation of mitochondrial function and the development of current mitochondria-targeted therapeutics to treat noncommunicable chronic diseases. Finally, we give an integrated vision of how mitochondrial damage is implicated in these metabolic diseases. © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities: Disease Gene

Keywords: mitochondria; cancer; cardiovascular diseases; insulin resistance; obesity

Mesh：

Substances：
Reactive Oxygen Species

Year: 2020 PMID： 32179913 PMCID： PMC7255501 DOI： 10.1210/endrev/bnaa005

Source DB: PubMed Journal: Endocr Rev ISSN： 0163-769X Impact factor: 19.871

310 in total

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22 in total

Review 1. Inter and Intracellular mitochondrial trafficking in health and disease.

Authors: Santhanam Shanmughapriya; Dianne Langford; Kalimuthusamy Natarajaseenivasan
Journal: Ageing Res Rev Date: 2020-07-23 Impact factor: 10.895

2. Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep.

Authors: Jane Stremming; Eileen I Chang; Leslie A Knaub; Michael L Armstrong; Peter R Baker; Stephanie R Wesolowski; Nichole Reisdorph; Jane E B Reusch; Laura D Brown
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Authors: Aranzazu M de Marañón; Pedro Díaz-Pozo; Francisco Canet; Noelia Díaz-Morales; Zaida Abad-Jiménez; Sandra López-Domènech; Teresa Vezza; Nadezda Apostolova; Carlos Morillas; Milagros Rocha; Víctor M Víctor
Journal: Redox Biol Date: 2022-05-17 Impact factor: 10.787

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Authors: Fuli Zheng; Zhousong Luo; Xinpei Lin; Wei Wang; Michael Aschner; Ping Cai; Yuan-Liang Wang; Wenya Shao; Guangxia Yu; Zhenkun Guo; Siying Wu; Huangyuan Li
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Authors: Celia Andrés Juan; José Manuel Pérez de la Lastra; Francisco J Plou; Eduardo Pérez-Lebeña
Journal: Int J Mol Sci Date: 2021-04-28 Impact factor: 5.923

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