Literature DB >> 32179529

Stp1 Loss of Function Promotes β-Lactam Resistance in Staphylococcus aureus That Is Independent of Classical Genes.

Aditi Chatterjee1, Raymond Poon1, Som S Chatterjee2.   

Abstract

β-Lactam resistance in Staphylococcus aureus limits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase, respectively, mediate serine-threonine kinase (STK) signaling. Loss-of-function point mutations in stp1 were detected among laboratory-passaged β-lactam-resistant S. aureus strains lacking mecA and blaZ, the major determinants of β-lactam resistance in the bacteria. Loss of Stp1 function facilitates β-lactam resistance of the bacteria.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  Staphylococcus aureus; Stp1; β-lactam resistance

Mesh：

Substances：

Year:  2020        PMID： 32179529      PMCID： PMC7269480          DOI： 10.1128/AAC.02222-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

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Review 2.  Role of eukaryotic-like serine/threonine kinases in bacterial cell division and morphogenesis.

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3.  PBP4 Mediates β-Lactam Resistance by Altered Function.

Authors:  Som S Chatterjee; Liang Chen; Aubre Gilbert; Thaina M da Costa; Vinod Nair; Sandip K Datta; Barry N Kreiswirth; Henry F Chambers
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

4.  Role of PknB kinase in antibiotic resistance and virulence in community-acquired methicillin-resistant Staphylococcus aureus strain USA300.

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5.  Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus.

Authors:  David R Cameron; Doyle V Ward; Xenia Kostoulias; Benjamin P Howden; Robert C Moellering; George M Eliopoulos; Anton Y Peleg
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Review 6.  The impact of serine/threonine phosphorylation in Staphylococcus aureus.

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7.  PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus.

Authors:  Liana C Chan; Aubre Gilbert; Li Basuino; Thaina M da Costa; Stephanie M Hamilton; Katia R Dos Santos; Henry F Chambers; Som S Chatterjee
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

8.  Characterization of a serine/threonine kinase involved in virulence of Staphylococcus aureus.

Authors:  Michel Débarbouillé; Shaynoor Dramsi; Olivier Dussurget; Marie-Anne Nahori; Elisabeth Vaganay; Grégory Jouvion; Alain Cozzone; Tarek Msadek; Bertrand Duclos
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Review 9.  Waves of resistance: Staphylococcus aureus in the antibiotic era.

Authors:  Henry F Chambers; Frank R Deleo
Journal:  Nat Rev Microbiol       Date:  2009-09       Impact factor: 60.633

Review 10.  Molecular Events for Promotion of Vancomycin Resistance in Vancomycin Intermediate Staphylococcus aureus.

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  2 in total

1.  In Vivo Detection of Cyclic-di-AMP in Staphylococcus aureus.

Authors:  Nagaraja Mukkayyan; Raymond Poon; Philipp N Sander; Li-Yin Lai; Zahra Zubair-Nizami; Ming C Hammond; Som S Chatterjee
Journal:  ACS Omega       Date:  2022-08-26

2.  In Vitro Selection of High-Level Beta-Lactam Resistance in Methicillin-Susceptible Staphylococcus aureus.

Authors:  Vladimir Gostev; Olga Kalinogorskaya; Ksenia Ivanova; Ekaterina Kalisnikova; Irina Lazareva; Polina Starkova; Sergey Sidorenko
Journal:  Antibiotics (Basel)       Date:  2021-05-26
  2 in total

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