Literature DB >> 28807923

PBP4 Mediates β-Lactam Resistance by Altered Function.

Som S Chatterjee1, Liang Chen2, Aubre Gilbert3, Thaina M da Costa3, Vinod Nair4, Sandip K Datta5, Barry N Kreiswirth2, Henry F Chambers3.   

Abstract

Penicillin binding protein 4 (PBP4) can provide high-level β-lactam resistance in Staphylococcus aureus A series of missense and promoter mutations associated with pbp4 were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the β-lactam resistance mediated by PBP4 and the promoter mutations lead to overexpression of pbp4 Our results also suggest a cooperative interplay among PBPs for β-lactam resistance.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  PBP4; Staphylococcus aureus; β-lactam resistance

Mesh：

Substances：

Year:  2017        PMID： 28807923      PMCID： PMC5655059          DOI： 10.1128/AAC.00932-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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Authors:  Tomasz A Łeski; Alexander Tomasz
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2.  In vitro activity of ceftaroline against clinical Staphylococcus aureus isolates collected during a national survey conducted in Belgian hospitals.

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Review 3.  Antimicrobial agents targeting bacterial cell walls and cell membranes.

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4.  PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus.

Authors:  Liana C Chan; Aubre Gilbert; Li Basuino; Thaina M da Costa; Stephanie M Hamilton; Katia R Dos Santos; Henry F Chambers; Som S Chatterjee
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

5.  Mutation of RNA polymerase β-subunit gene promotes heterogeneous-to-homogeneous conversion of β-lactam resistance in methicillin-resistant Staphylococcus aureus.

Authors:  Yoshifumi Aiba; Yuki Katayama; Tomomi Hishinuma; Hiroko Murakami-Kuroda; Longzhu Cui; Keiichi Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  2013-07-22       Impact factor: 5.191

6.  Improved lux reporters for use in Staphylococcus aureus.

Authors:  Lili Rosana Mesak; Grace Yim; Julian Davies
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Review 7.  Waves of resistance: Staphylococcus aureus in the antibiotic era.

Authors:  Henry F Chambers; Frank R Deleo
Journal:  Nat Rev Microbiol       Date:  2009-09       Impact factor: 60.633

Review 8.  The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis.

Authors:  Eric Sauvage; Frédéric Kerff; Mohammed Terrak; Juan A Ayala; Paulette Charlier
Journal:  FEMS Microbiol Rev       Date:  2008-02-11       Impact factor: 16.408

9.  Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon.

Authors:  S Utaida; P M Dunman; D Macapagal; E Murphy; S J Projan; V K Singh; R K Jayaswal; B J Wilkinson
Journal:  Microbiology       Date:  2003-10       Impact factor: 2.777

10.  Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance.

Authors:  Alexander L Greninger; Som S Chatterjee; Liana C Chan; Stephanie M Hamilton; Henry F Chambers; Charles Y Chiu
Journal:  PLoS One       Date:  2016-02-18       Impact factor: 3.240
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  13 in total

1.  Revisiting the β-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach.

Authors:  Shiqi Xiao; Haidan Guo; Warren S Weiner; Clinton Maddox; Chunhong Mao; Hendra Gunosewoyo; Shaaretha Pelly; E Lucile White; Lynn Rasmussen; Frank J Schoenen; Jeffrey Aubé; William R Bishai; Shichun Lun
Journal:  Antimicrob Agents Chemother       Date:  2019-10-22       Impact factor: 5.191

2.  Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes.

Authors:  M Angeles Argudín; S Roisin; L Nienhaus; M Dodémont; R de Mendonça; C Nonhoff; A Deplano; O Denis
Journal:  Antimicrob Agents Chemother       Date:  2018-06-26       Impact factor: 5.191

Review 3.  Constructing and deconstructing the bacterial cell wall.

Authors:  Jed F Fisher; Shahriar Mobashery
Journal:  Protein Sci       Date:  2019-11-20       Impact factor: 6.725

4.  Loss of GdpP Function in Staphylococcus aureus Leads to β-Lactam Tolerance and Enhanced Evolution of β-Lactam Resistance.

Authors:  Raymond Poon; Li Basuino; Nidhi Satishkumar; Aditi Chatterjee; Nagaraja Mukkayyan; Emma Buggeln; Liusheng Huang; Vinod Nair; Maria A Argudín; Sandip K Datta; Henry F Chambers; Som S Chatterjee
Journal:  Antimicrob Agents Chemother       Date:  2021-11-29       Impact factor: 5.938

5.  Stp1 Loss of Function Promotes β-Lactam Resistance in Staphylococcus aureus That Is Independent of Classical Genes.

Authors:  Aditi Chatterjee; Raymond Poon; Som S Chatterjee
Journal:  Antimicrob Agents Chemother       Date:  2020-05-21       Impact factor: 5.191

6.  Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus.

Authors:  J Andrew N Alexander; Som S Chatterjee; Stephanie M Hamilton; Lindsay D Eltis; Henry F Chambers; Natalie C J Strynadka
Journal:  J Biol Chem       Date:  2018-10-26       Impact factor: 5.157

7.  In vitro and in vivo activity of d-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus.

Authors:  Qing Wang; Yuemeng Lv; Jing Pang; Xue Li; Xi Lu; Xiukun Wang; Xinxin Hu; Tongying Nie; Xinyi Yang; Yan Q Xiong; Jiandong Jiang; Congran Li; Xuefu You
Journal:  Acta Pharm Sin B       Date:  2019-01-31       Impact factor: 11.413

8.  Recognition of Peptidoglycan Fragments by the Transpeptidase PBP4 From Staphylococcus aureus.

Authors:  Roberto Maya-Martinez; J Andrew N Alexander; Christian F Otten; Isabel Ayala; Daniela Vollmer; Joe Gray; Catherine M Bougault; Alister Burt; Cédric Laguri; Matthieu Fonvielle; Michel Arthur; Natalie C J Strynadka; Waldemar Vollmer; Jean-Pierre Simorre
Journal:  Front Microbiol       Date:  2019-01-18       Impact factor: 5.640

Review 9.  PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance.

Authors:  Thaina M da Costa; Carolina R de Oliveira; Henry F Chambers; Som S Chatterjee
Journal:  Microorganisms       Date:  2018-06-22

10.  Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice.

Authors:  Elysia A Masters; Karen L de Mesy Bentley; Ann Lindley Gill; Stephanie P Hao; Chad A Galloway; Alec T Salminen; Diamond R Guy; James L McGrath; Hani A Awad; Steven R Gill; Edward M Schwarz
Journal:  PLoS Pathog       Date:  2020-10-22       Impact factor: 6.823
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