Olaitan Okunoye1, Gotaro Kojima2, Louise Marston2, Kate Walters2, Anette Schrag3. 1. Department of Clinical and Movement Neurosciences, University College London, UK. Electronic address: olaitan.okunoye.16@ucl.ac.uk. 2. Department of Primary Care and Population Health, University College London, UK. 3. Department of Clinical and Movement Neurosciences, University College London, UK.
Abstract
INTRODUCTION: Parkinson's disease (PD) is associated with an increased risk of admission to hospital; however data on the main reasons for admission are lacking. Our objective was to determine the pooled prevalence of the most common factors leading to admission among people with Parkinson's disease. METHODOLOGY: A systematic literature search was conducted in 11 electronic databases. We included all studies providing reasons for admissions among PD patients without restrictions to diagnostic criteria of PD, language or year of study. In the included studies, methodological quality, publication bias and heterogeneity were assessed. Meta-analysis was performed using random-effects models to calculate the pooled estimates of the identified top factors that lead to admission among people with PD. RESULTS: A total of 7283 studies were identified of which nine studies including 7162 people with PD were included in this review. There was a high degree of heterogeneity between studies regarding reasons for hospitalisation. The pooled prevalence of the topmost reasons for hospitalisation among people with PD was 22% (95%CI 16.0%–30.0%) for infections (mainly urinary tract infections and pneumonia); 19% (95%CI 13.0%–27.0%) for worsening motor manifestations of PD; 18% (95%CI 14.0%–21.0%) for falls/fractures; 13% (95%CI 9.0%–18%) for cardiovascular co-morbidities; 8% (95%CI 4.0%–13.0%) for neuropsychiatric and 7% (95%CI 4.0%–11.0%) for gastrointestinal complications. CONCLUSION: The main reasons for hospitalisation among people with PD are infections, worsening motor features, falls/fractures, cardiovascular co-morbidities, neuropsychiatric and gastrointestinal complications. Further research is needed on targeting and implementing preventative strategies.
INTRODUCTION:Parkinson's disease (PD) is associated with an increased risk of admission to hospital; however data on the main reasons for admission are lacking. Our objective was to determine the pooled prevalence of the most common factors leading to admission among people with Parkinson's disease. METHODOLOGY: A systematic literature search was conducted in 11 electronic databases. We included all studies providing reasons for admissions among PDpatients without restrictions to diagnostic criteria of PD, language or year of study. In the included studies, methodological quality, publication bias and heterogeneity were assessed. Meta-analysis was performed using random-effects models to calculate the pooled estimates of the identified top factors that lead to admission among people with PD. RESULTS: A total of 7283 studies were identified of which nine studies including 7162 people with PD were included in this review. There was a high degree of heterogeneity between studies regarding reasons for hospitalisation. The pooled prevalence of the topmost reasons for hospitalisation among people with PD was 22% (95%CI 16.0%–30.0%) for infections (mainly urinary tract infections and pneumonia); 19% (95%CI 13.0%–27.0%) for worsening motor manifestations of PD; 18% (95%CI 14.0%–21.0%) for falls/fractures; 13% (95%CI 9.0%–18%) for cardiovascular co-morbidities; 8% (95%CI 4.0%–13.0%) for neuropsychiatric and 7% (95%CI 4.0%–11.0%) for gastrointestinal complications. CONCLUSION: The main reasons for hospitalisation among people with PD are infections, worsening motor features, falls/fractures, cardiovascular co-morbidities, neuropsychiatric and gastrointestinal complications. Further research is needed on targeting and implementing preventative strategies.
Authors: S Greten; J I Müller-Funogea; O Krause; M Klietz; F Wegner; G U Höglinger; N Simon; U Junius-Walker; S Gerbel Journal: J Neural Transm (Vienna) Date: 2020-12-01 Impact factor: 3.575
Authors: Álvaro Réa-Neto; Bruna C Dal Vesco; Rafaella S Bernardelli; Aline M Kametani; Mirella C Oliveira; Hélio A G Teive Journal: Parkinsons Dis Date: 2021-11-05
Authors: Amr Ehab El-Qushayri; Sherief Ghozy; Abdullah Reda; Ahmed Mostafa Ahmed Kamel; Alzhraa Salah Abbas; Adam A Dmytriw Journal: Rev Med Virol Date: 2021-07-14 Impact factor: 11.043