Ekawat Vichayanrat1,2, Claire Hentzen1,3, Amit Batla4, Sara Simeoni1,4, Valeria Iodice2,4, Jalesh N Panicker5,6. 1. Department of Uro‑Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. 2. Autonomic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. 3. Sorbonne Université, GRC 01, GREEN Groupe de Recherche Clinique en Neuro-Urologie, AP-HP, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France. 4. Faculty of Brain Sciences, UCL Queen Square Institute of Neurology, University College London, London, UK. 5. Department of Uro‑Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. j.panicker@ucl.ac.uk. 6. Faculty of Brain Sciences, UCL Queen Square Institute of Neurology, University College London, London, UK. j.panicker@ucl.ac.uk.
Abstract
PURPOSE OF REVIEW: The aim of this review is to outline the clinical presentation, pathophysiology and evaluation of lower urinary tract (LUT) dysfunction in Parkinson's disease and other parkinsonian syndromes including multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration. RECENT FINDINGS: LUT dysfunction commonly occurs in neurological disorders, including patients with parkinsonian syndromes. The pattern of LUT dysfunction and its severity are variable, depending upon the site of lesion within the neural pathways. Parkinsonian syndromes are broadly divided into Parkinson's disease (PD) and a typical parkinsonian syndromes such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Different parkinsonian syndromes have distinct clinical features (e.g. dysautonomia, early dementia, supranuclear gaze palsy, higher cortical signs), and the pattern of LUT dysfunction and its severity can differ. CONCLUSIONS: LUT dysfunction is a common feature in patients with parkinsonian syndromes. Recognising the pattern of LUT dysfunction during the assessment of these patients can help management and possibly facilitate an earlier diagnosis.
PURPOSE OF REVIEW: The aim of this review is to outline the clinical presentation, pathophysiology and evaluation of lower urinary tract (LUT) dysfunction in Parkinson's disease and other parkinsonian syndromes including multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration. RECENT FINDINGS:LUT dysfunction commonly occurs in neurological disorders, including patients with parkinsonian syndromes. The pattern of LUT dysfunction and its severity are variable, depending upon the site of lesion within the neural pathways. Parkinsonian syndromes are broadly divided into Parkinson's disease (PD) and a typical parkinsonian syndromes such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Different parkinsonian syndromes have distinct clinical features (e.g. dysautonomia, early dementia, supranuclear gaze palsy, higher cortical signs), and the pattern of LUT dysfunction and its severity can differ. CONCLUSIONS:LUT dysfunction is a common feature in patients with parkinsonian syndromes. Recognising the pattern of LUT dysfunction during the assessment of these patients can help management and possibly facilitate an earlier diagnosis.
Authors: Pablo Martinez-Martin; Anthony H V Schapira; Fabrizio Stocchi; Kapil Sethi; Per Odin; Graeme MacPhee; Richard G Brown; Yogini Naidu; Lisa Clayton; Kazuo Abe; Yoshio Tsuboi; Dough MacMahon; Paolo Barone; Martin Rabey; Ubaldo Bonuccelli; Alison Forbes; Kieran Breen; Susanne Tluk; C Warren Olanow; Sue Thomas; David Rye; Annette Hand; Adrian J Williams; William Ondo; K Ray Chaudhuri Journal: Mov Disord Date: 2007-08-15 Impact factor: 10.338