Literature DB >> 32152912

KISS1 in metastatic cancer research and treatment: potential and paradoxes.

Thuc Ly1, Sitaram Harihar2, Danny R Welch3,4.   

Abstract

The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm regarding KISS1 has cumulated in clinical trials in multiple fields related to reproduction and metabolism. But its cancer therapeutic space is unsettled. This review focuses on collating data from cancer and non-cancer fields in order to understand shared and disparate signaling that might inform clinical development in the cancer therapeutic and biomarker space. Research has focused on amino acid residues 68-121 (kisspeptin 54), binding to the KISS1 receptor and cellular responses. Evidence and counterevidence regarding this canonical pathway require closer look at the covariates so that the incredible potential of KISS1 can be realized.

Entities:  

Keywords:  Dormancy; G protein-coupled receptor; KISS1; KISS1R; Metastasis; Metastasis suppressor

Mesh：

Substances：

Year:  2020        PMID： 32152912      PMCID： PMC7483209          DOI： 10.1007/s10555-020-09868-9

Source DB:  PubMed          Journal:  Cancer Metastasis Rev        ISSN： 0167-7659            Impact factor:   9.264


  156 in total

Review 1.  Kisspeptin as a potential biomarker throughout pregnancy.

Authors:  Kai-Lun Hu; Hongcui Zhao; Yang Yu; Rong Li
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2019-07-16       Impact factor: 2.435

Review 2.  The Kiss1 system and polycystic ovary syndrome: lessons from physiology and putative pathophysiologic implications.

Authors:  Selma F Witchel; Manuel Tena-Sempere
Journal:  Fertil Steril       Date:  2013-07       Impact factor: 7.329

3.  The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.

Authors:  M Kotani; M Detheux; A Vandenbogaerde; D Communi; J M Vanderwinden; E Le Poul; S Brézillon; R Tyldesley; N Suarez-Huerta; F Vandeput; C Blanpain; S N Schiffmann; G Vassart; M Parmentier
Journal:  J Biol Chem       Date:  2001-07-16       Impact factor: 5.157

4.  Inactivating KISS1 mutation and hypogonadotropic hypogonadism.

Authors:  A Kemal Topaloglu; Javier A Tello; L Damla Kotan; Mehmet N Ozbek; M Bertan Yilmaz; Seref Erdogan; Fatih Gurbuz; Fatih Temiz; Robert P Millar; Bilgin Yuksel
Journal:  N Engl J Med       Date:  2012-02-16       Impact factor: 91.245

5.  Kisspeptin: beyond the brain.

Authors:  Moshmi Bhattacharya; Andy V Babwah
Journal:  Endocrinology       Date:  2015-01-15       Impact factor: 4.736

6.  Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.

Authors:  T Ohtaki; Y Shintani; S Honda; H Matsumoto; A Hori; K Kanehashi; Y Terao; S Kumano; Y Takatsu; Y Masuda; Y Ishibashi; T Watanabe; M Asada; T Yamada; M Suenaga; C Kitada; S Usuki; T Kurokawa; H Onda; O Nishimura; M Fujino
Journal:  Nature       Date:  2001-05-31       Impact factor: 49.962

7.  AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.

Authors:  A I Muir; L Chamberlain; N A Elshourbagy; D Michalovich; D J Moore; A Calamari; P G Szekeres; H M Sarau; J K Chambers; P Murdock; K Steplewski; U Shabon; J E Miller; S E Middleton; J G Darker; C G Larminie; S Wilson; D J Bergsma; P Emson; R Faull; K L Philpott; D C Harrison
Journal:  J Biol Chem       Date:  2001-05-31       Impact factor: 5.157

8.  Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways.

Authors:  Michelle L Gottsch; Víctor M Navarro; Zhen Zhao; Christine Glidewell-Kenney; Jeffrey Weiss; J Larry Jameson; Donald K Clifton; Jon E Levine; Robert A Steiner
Journal:  J Neurosci       Date:  2009-07-22       Impact factor: 6.167

9.  High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.

Authors:  Robert Brommage; Jeff Liu; Gwenn M Hansen; Laura L Kirkpatrick; David G Potter; Arthur T Sands; Brian Zambrowicz; David R Powell; Peter Vogel
Journal:  Bone Res       Date:  2014-10-28       Impact factor: 13.567

Review 10.  The roles of kisspeptin in the mechanism underlying reproductive functions in mammals.

Authors:  Yoshihisa Uenoyama; Naoko Inoue; Kei-Ichiro Maeda; Hiroko Tsukamura
Journal:  J Reprod Dev       Date:  2018-10-08       Impact factor: 2.214
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  5 in total

Review 1.  Vascular mimicry: Triggers, molecular interactions and in vivo models.

Authors:  Stephen L Wechman; Luni Emdad; Devanand Sarkar; Swadesh K Das; Paul B Fisher
Journal:  Adv Cancer Res       Date:  2020-07-16       Impact factor: 6.242

2.  Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model.

Authors:  Stephania Guzman; Magdalena Dragan; Hyokjoon Kwon; Vanessa de Oliveira; Shivani Rao; Vrushank Bhatt; Katarzyna M Kalemba; Ankit Shah; Vinod K Rustgi; He Wang; Paul R Bech; Ali Abbara; Chioma Izzi-Engbeaya; Pinelopi Manousou; Jessie Y Guo; Grace L Guo; Sally Radovick; Waljit S Dhillo; Fredric E Wondisford; Andy V Babwah; Moshmi Bhattacharya
Journal:  J Clin Invest       Date:  2022-05-16       Impact factor: 19.456

Review 3.  The Role of Adipokines in Pancreatic Cancer.

Authors:  Qi Wang; Huizhi Wang; Yuntao Ding; Mengtian Wan; Min Xu
Journal:  Front Oncol       Date:  2022-07-08       Impact factor: 5.738

Review 4.  Novel Insight into the Role of the Kiss1/GPR54 System in Energy Metabolism in Major Metabolic Organs.

Authors:  Xuehan Li; Chunyu Liang; Yi Yan
Journal:  Cells       Date:  2022-10-06       Impact factor: 7.666

5.  Up-regulation of KISS1 as a novel target of Let-7i in melanoma serves as a potential suppressor of migration and proliferation in vitro.

Authors:  Haider A Alkafaji; Ahmed Raji; Heshu S Rahman; Angelina O Zekiy; Ali Adili; Mohammadmahdi Jalili; Tahereh Hojjatipour; Angel Cid-Arregui; Navid Shomali; Saeed Tarzi; Rozita Tamjidifar; Ramin Heshmati; Faroogh Marofi; Morteza Akbari; Ali Hasanzadeh; Mina Deljavanghodrati; Mostafa Jarahian; Siamak Sandoghchian Shotorbani
Journal:  J Cell Mol Med       Date:  2021-06-06       Impact factor: 5.310
  5 in total

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