Carolina Barnett1,2, Jordan R Green3,4, Reeman Marzouqah5, Kaila L Stipancic3, James D Berry6, Lawrence Korngut7, Angela Genge8, Christen Shoesmith9, Hannah Briemberg10, Agessandro Abrahao11,12, Sanjay Kalra13,14, Lorne Zinman11,12,15, Yana Yunusova5,12,16. 1. Division of Neurology, Department of Medicine, University of Toronto and University Health Network, Toronto, Canada. 2. Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. 3. Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA, USA. 4. Speech and Hearing Biosciences and Technology Program, Harvard University, Cambridge, MA, USA. 5. Department of Speech-Language Pathology, University of Toronto, Toronto, Canada. 6. Harvard Medical School, Department of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA,. 7. Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. 8. Montreal Neurological Institute, Neurosurgery, McGill University, Montreal, Canada. 9. Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada. 10. Division of Neurology, University of British Columbia, Vancouver, Canada. 11. Department of Medicine, Division of Neurology, Sunnybrook Health Sciences Centre, Toronto, Canada. 12. Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada. 13. Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada. 14. Division of Neurology, University of Alberta, Edmonton, Canada. 15. L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, University of Toronto, Toronto, Canada, and. 16. Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.
Abstract
Objective: The use of speech measures is becoming a common practice in the assessment of bulbar disease progression in amyotrophic lateral sclerosis (ALS). This study aimed to establish psychometric properties (e.g. reliability, validity, sensitivity, specificity) of speech and pause timing measures during a standardized passage. Methods: A large number of passage recordings (ALS N = 775; Neurotypical controls N = 323) was analyzed using a semi-automatic method (Speech and Pause Analysis, SPA). Results: The results revealed acceptable reliability of the speech and pause measures across repeated recording by the control participants. Strong construct validity was established via significant group differences between patients and controls and correlation statistics with clinical measures of overall ALS and bulbar disease severity. Speaking rate, pause events, and mean pause duration were able to detect ALS participants at the presymptomatic stage of bulbar disease with a good discrimination ability (AUC 0.81). Conclusions: Based on the current psychometric evaluation, performing passage recording and speech and pause timing analysis was deemed useful for detecting early and progressive changes associated with bulbar ALS.
Objective: The use of speech measures is becoming a common practice in the assessment of bulbar disease progression in amyotrophic lateral sclerosis (ALS). This study aimed to establish psychometric properties (e.g. reliability, validity, sensitivity, specificity) of speech and pause timing measures during a standardized passage. Methods: A large number of passage recordings (ALS N = 775; Neurotypical controls N = 323) was analyzed using a semi-automatic method (Speech and Pause Analysis, SPA). Results: The results revealed acceptable reliability of the speech and pause measures across repeated recording by the control participants. Strong construct validity was established via significant group differences between patients and controls and correlation statistics with clinical measures of overall ALS and bulbar disease severity. Speaking rate, pause events, and mean pause duration were able to detect ALS participants at the presymptomatic stage of bulbar disease with a good discrimination ability (AUC 0.81). Conclusions: Based on the current psychometric evaluation, performing passage recording and speech and pause timing analysis was deemed useful for detecting early and progressive changes associated with bulbar ALS.
Authors: Martin Hecht; Thomas Hillemacher; Elmar Gräsel; Sebastian Tigges; Martin Winterholler; Dieter Heuss; Max-Josef Hilz; Bernhard Neundörfer Journal: Amyotroph Lateral Scler Other Motor Neuron Disord Date: 2002-12
Authors: Kristen M Allison; Yana Yunusova; Thomas F Campbell; Jun Wang; James D Berry; Jordan R Green Journal: Amyotroph Lateral Scler Frontotemporal Degener Date: 2017-03-29 Impact factor: 4.092
Authors: Richard Smith; Erik Pioro; Kathleen Myers; Michael Sirdofsky; Kimberly Goslin; Gregg Meekins; Hong Yu; James Wymer; Merit Cudkowicz; Eric A Macklin; David Schoenfeld; Gary Pattee Journal: Neurotherapeutics Date: 2017-07 Impact factor: 7.620
Authors: Jordan R Green; Kristen M Allison; Claire Cordella; Brian D Richburg; Gary L Pattee; James D Berry; Eric A Macklin; Erik P Pioro; Richard A Smith Journal: Br J Clin Pharmacol Date: 2018-10-01 Impact factor: 4.335
Authors: Yana Yunusova; Jamal Ansari; Joel Ramirez; Sanjana Shellikeri; Greg J Stanisz; Sandra E Black; Susan M Gillingham; Alex Kiss; Donald T Stuss; Lorne Zinman Journal: Behav Neurol Date: 2019-03-13 Impact factor: 3.342
Authors: Chelsea Tanchip; Diego L Guarin; Scotia McKinlay; Carolina Barnett; Sanjay Kalra; Angela Genge; Lawrence Korngut; Jordan R Green; James Berry; Lorne Zinman; Azadeh Yadollahi; Agessandro Abrahao; Yana Yunusova Journal: J Speech Lang Hear Res Date: 2022-02-16 Impact factor: 2.674
Authors: Kaila L Stipancic; Kira M Palmer; Hannah P Rowe; Yana Yunusova; James D Berry; Jordan R Green Journal: J Speech Lang Hear Res Date: 2021-11-11 Impact factor: 2.674
Authors: Yana Yunusova; Ashley Waito; Carolina Barnett; Anna Huynh; Rosemary Martino; Agessandro Abrahao; Gary L Pattee; James D Berry; Lorne Zinman; Jordan R Green Journal: BMJ Open Date: 2022-03-08 Impact factor: 2.692
Authors: Marziye Eshghi; Yana Yunusova; Kathryn P Connaghan; Bridget J Perry; Marc F Maffei; James D Berry; Lorne Zinman; Sanjay Kalra; Lawrence Korngut; Angela Genge; Annie Dionne; Jordan R Green Journal: Sci Rep Date: 2022-09-20 Impact factor: 4.996
Authors: Kaila L Stipancic; Yana Yunusova; Thomas F Campbell; Jun Wang; James D Berry; Jordan R Green Journal: Front Neurol Date: 2021-06-16 Impact factor: 4.003