| Literature DB >> 32110433 |
Kay Pepin1, Roger Grimm2, Soudabeh Kargar3, B Matthew Howe2, Karen Fritchie4, Matthew Frick2, Doris Wenger2, Scott Okuno5, Richard Ehman2, Kiaran McGee2, Sarah James1, Nadia Laack1, Michael Herman1, Deanna Pafundi1.
Abstract
Soft tissue sarcomas are a rare and heterogeneous group of malignancies that present significant diagnostic and therapeutic challenges. Patient stratification based on tumor aggressiveness and early therapeutic response based on quantitative imaging may improve prediction of treatment response and the evaluation of new treatment strategies in clinical trials. The purpose of this pilot study was to determine the technical feasibility of magnetic resonance elastography (MRE) and dynamic contrast-enhanced (DCE) MRI for the evaluation of sarcoma stiffness and perfusion in 9 patients with histologically confirmed sarcoma. Additionally, we assessed the feasibility of utilizing MRE and DCE-MRI for the early evaluation of response to radiation therapy in 4 patients to determine the utility of further evaluation in a larger cohort study. Tumor size, stiffness, and perfusion parameters all decreased from baseline at the time of the pre-surgery or follow-up MRI, and results were compared to pathology or conventional imaging. MRE and DCE-MRI may be useful for the quantitative evaluation of tumor stiffness and perfusion, and therapy response assessment in soft tissue sarcomas.Entities:
Year: 2019 PMID： 32110433 PMCID： PMC7045581 DOI： 10.1088/2057-1976/ab2175
Source DB: PubMed Journal: Biomed Phys Eng Express ISSN： 2057-1976