Literature DB >> 32100807

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates.

Johnathan C Maza1, Alexandra V Ramsey1, Meire Mehare1, Shane W Krska2, Craig A Parish2, Matthew B Francis3.   

Abstract

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.

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Year:  2020        PMID： 32100807      PMCID： PMC7213020          DOI： 10.1039/d0ob00211a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  25 in total

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3.  Site-selective protein-modification chemistry for basic biology and drug development.

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4.  Recent advances in the construction of antibody-drug conjugates.

Authors:  Vijay Chudasama; Antoine Maruani; Stephen Caddick
Journal:  Nat Chem       Date:  2016-01-04       Impact factor: 24.427

5.  A tale of two tails: why are terminal residues of proteins exposed?

Authors:  Etai Jacob; Ron Unger
Journal:  Bioinformatics       Date:  2007-01-15       Impact factor: 6.937

6.  Nucleophilic catalysis of oxime ligation.

Authors:  Anouk Dirksen; Tilman M Hackeng; Philip E Dawson
Journal:  Angew Chem Int Ed Engl       Date:  2006-11-20       Impact factor: 15.336

Review 7.  Biomolecular interaction analysis: affinity biosensor technologies for functional analysis of proteins.

Authors:  M Malmqvist; R Karlsson
Journal:  Curr Opin Chem Biol       Date:  1997-10       Impact factor: 8.822

Review 8.  Targeting the N terminus for site-selective protein modification.

Authors:  Christian B Rosen; Matthew B Francis
Journal:  Nat Chem Biol       Date:  2017-06-20       Impact factor: 15.040

9.  Site-specific protein transamination using N-methylpyridinium-4-carboxaldehyde.

Authors:  Leah S Witus; Chawita Netirojjanakul; Kanwal S Palla; Ellen M Muehl; Chih-Hisang Weng; Anthony T Iavarone; Matthew B Francis
Journal:  J Am Chem Soc       Date:  2013-11-05       Impact factor: 15.419

10.  N-terminal modification of proteins with o-aminophenols.

Authors:  Allie C Obermeyer; John B Jarman; Matthew B Francis
Journal:  J Am Chem Soc       Date:  2014-06-25       Impact factor: 15.419
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  1 in total

1.  Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine-Cysteine Bond Formation.

Authors:  Marco J Lobba; Christof Fellmann; Alan M Marmelstein; Johnathan C Maza; Elijah N Kissman; Stephanie A Robinson; Brett T Staahl; Cole Urnes; Rachel J Lew; Casey S Mogilevsky; Jennifer A Doudna; Matthew B Francis
Journal:  ACS Cent Sci       Date:  2020-08-21       Impact factor: 14.553
  1 in total

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