| Literature DB >> 32089215 |
Kelly L Bolton1, Ahmet Zehir2, Ryan N Ptashkin2, Minal Patel3, Dipti Gupta4, Robert Sidlow5, Elli Papaemmanuil6, Michael F Berger7, Ross L Levine8.
Abstract
The acquisition of mutations in hematologic stem cells (clonal hematopoiesis) is common with normal aging and can be identified as an incidental finding through clinical genetic testing. Clonal hematopoiesis is associated with a heightened risk of developing hematologic neoplasms (especially myeloid) and accelerated atherosclerotic cardiovascular disease. This article discusses a multidisciplinary clinical approach to the management of patients with clonal hematopoiesis. Key areas of research needed to establish evidence-based clinical care guidelines and intervention strategies for individuals with clonal hematopoiesis are discussed.Entities:
Keywords: Clonal cytopenias of uncertain significance; Clonal hematopoiesis; Clonal hematopoiesis of indeterminate significance
Mesh：
Substances：
Year: 2020 PMID： 32089215 DOI： 10.1016/j.hoc.2019.11.006
Source DB: PubMed Journal: Hematol Oncol Clin North Am ISSN： 0889-8588 Impact factor: 3.722