Christopher Maximilian Arends1, Frederik Damm2,3,4. 1. Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland. 2. Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland. frederik.damm@charite.de. 3. Deutsches Konsortium für Translationale Krebsforschung (DKTK), Heidelberg, Deutschland. frederik.damm@charite.de. 4. Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland. frederik.damm@charite.de.
Abstract
BACKGROUND: Clonal hematopoiesis (CH) is a premalignant state of the hematopoietic system that frequently occurs in old age and is associated with an elevated cardiovascular risk and higher overall mortality. AIM: The prevalence and clinical implications of CH in patients with solid neoplasms were examined. MATERIAL AND METHODS: A review, summary and discussion of the recent literature was carried out. RESULTS: CH occurs in 20-30% of patients with solid neoplasms. In the molecular diagnostics of tumor or cell-free DNA from plasma, CH mutations can be falsely interpreted as tumor mutations. CH and in particular mutations in the genes of the DNA damage repair machinery are associated with a higher risk of therapy-associated myeloid neoplasms (t-MN) following chemotherapy, radiotherapy and poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor therapy. CONCLUSION: CH is a frequent phenomenon in patients with solid neoplasms. It has high clinical relevance due to the associated risk of t‑MN. More research is needed for a better understanding of the role of CH in this patient collective and to derive evidence-based recommendations for action.
BACKGROUND: Clonal hematopoiesis (CH) is a premalignant state of the hematopoietic system that frequently occurs in old age and is associated with an elevated cardiovascular risk and higher overall mortality. AIM: The prevalence and clinical implications of CH in patients with solid neoplasms were examined. MATERIAL AND METHODS: A review, summary and discussion of the recent literature was carried out. RESULTS: CH occurs in 20-30% of patients with solid neoplasms. In the molecular diagnostics of tumor or cell-free DNA from plasma, CH mutations can be falsely interpreted as tumor mutations. CH and in particular mutations in the genes of the DNA damage repair machinery are associated with a higher risk of therapy-associated myeloid neoplasms (t-MN) following chemotherapy, radiotherapy and poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor therapy. CONCLUSION: CH is a frequent phenomenon in patients with solid neoplasms. It has high clinical relevance due to the associated risk of t‑MN. More research is needed for a better understanding of the role of CH in this patient collective and to derive evidence-based recommendations for action.
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Authors: Alexander G Bick; Joshua S Weinstock; Satish K Nandakumar; Charles P Fulco; Erik L Bao; Seyedeh M Zekavat; Mindy D Szeto; Xiaotian Liao; Matthew J Leventhal; Joseph Nasser; Kyle Chang; Cecelia Laurie; Bala Bharathi Burugula; Christopher J Gibson; Amy E Lin; Margaret A Taub; Francois Aguet; Kristin Ardlie; Braxton D Mitchell; Kathleen C Barnes; Arden Moscati; Myriam Fornage; Susan Redline; Bruce M Psaty; Edwin K Silverman; Scott T Weiss; Nicholette D Palmer; Ramachandran S Vasan; Esteban G Burchard; Sharon L R Kardia; Jiang He; Robert C Kaplan; Nicholas L Smith; Donna K Arnett; David A Schwartz; Adolfo Correa; Mariza de Andrade; Xiuqing Guo; Barbara A Konkle; Brian Custer; Juan M Peralta; Hongsheng Gui; Deborah A Meyers; Stephen T McGarvey; Ida Yii-Der Chen; M Benjamin Shoemaker; Patricia A Peyser; Jai G Broome; Stephanie M Gogarten; Fei Fei Wang; Quenna Wong; May E Montasser; Michelle Daya; Eimear E Kenny; Kari E North; Lenore J Launer; Brian E Cade; Joshua C Bis; Michael H Cho; Jessica Lasky-Su; Donald W Bowden; L Adrienne Cupples; Angel C Y Mak; Lewis C Becker; Jennifer A Smith; Tanika N Kelly; Stella Aslibekyan; Susan R Heckbert; Hemant K Tiwari; Ivana V Yang; John A Heit; Steven A Lubitz; Jill M Johnsen; Joanne E Curran; Sally E Wenzel; Daniel E Weeks; Dabeeru C Rao; Dawood Darbar; Jee-Young Moon; Russell P Tracy; Erin J Buth; Nicholas Rafaels; Ruth J F Loos; Peter Durda; Yongmei Liu; Lifang Hou; Jiwon Lee; Priyadarshini Kachroo; Barry I Freedman; Daniel Levy; Lawrence F Bielak; James E Hixson; James S Floyd; Eric A Whitsel; Patrick T Ellinor; Marguerite R Irvin; Tasha E Fingerlin; Laura M Raffield; Sebastian M Armasu; Marsha M Wheeler; Ester C Sabino; John Blangero; L Keoki Williams; Bruce D Levy; Wayne Huey-Herng Sheu; Dan M Roden; Eric Boerwinkle; JoAnn E Manson; Rasika A Mathias; Pinkal Desai; Kent D Taylor; Andrew D Johnson; Paul L Auer; Charles Kooperberg; Cathy C Laurie; Thomas W Blackwell; Albert V Smith; Hongyu Zhao; Ethan Lange; Leslie Lange; Stephen S Rich; Jerome I Rotter; James G Wilson; Paul Scheet; Jacob O Kitzman; Eric S Lander; Jesse M Engreitz; Benjamin L Ebert; Alexander P Reiner; Siddhartha Jaiswal; Gonçalo Abecasis; Vijay G Sankaran; Sekar Kathiresan; Pradeep Natarajan Journal: Nature Date: 2020-10-14 Impact factor: 69.504