Literature DB >> 32089119

Exploring modularity in biological networks.

Maria Serban1.   

Abstract

Network theoretical approaches have shaped our understanding of many different kinds of biological modularity. This essay makes the case that to capture these contributions, it is useful to think about the role of network models in exploratory research. The overall point is that it is possible to provide a systematic analysis of the exploratory functions of network models in bioscientific research. Using two examples from molecular and developmental biology, I argue that often the same modelling approach can perform one or more exploratory functions, such as introducing new directions of research, offering a complementary set of concepts, methods and algorithms for individuating important features of natural phenomena, generating proofs of principle demonstrations and potential explanations for phenomena of interest and enlarging the scope of certain research agendas. This article is part of the theme issue 'Unifying the essential concepts of biological networks: biological insights and philosophical foundations'.

Keywords:  exploratory; models; modularity; networks

Mesh:

Year:  2020        PMID: 32089119      PMCID: PMC7061960          DOI: 10.1098/rstb.2019.0316

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN: 0962-8436            Impact factor:   6.237


  16 in total

1.  Hierarchical organization of modularity in metabolic networks.

Authors:  E Ravasz; A L Somera; D A Mongru; Z N Oltvai; A L Barabási
Journal:  Science       Date:  2002-08-30       Impact factor: 47.728

2.  Modularity and community structure in networks.

Authors:  M E J Newman
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-24       Impact factor: 11.205

Review 3.  The road to modularity.

Authors:  Günter P Wagner; Mihaela Pavlicev; James M Cheverud
Journal:  Nat Rev Genet       Date:  2007-12       Impact factor: 53.242

4.  On microRNA and the need for exploratory experimentation in post-genomic molecular biology.

Authors:  Richard M Burian
Journal:  Hist Philos Life Sci       Date:  2007       Impact factor: 1.205

5.  Exploratory experimentation and scientific practice: metagenomics and the proteorhodopsin case.

Authors:  Maureen A O'Malley
Journal:  Hist Philos Life Sci       Date:  2007       Impact factor: 1.205

6.  Varieties of exploratory experimentation in nanotoxicology.

Authors:  Kevin C Elliott
Journal:  Hist Philos Life Sci       Date:  2007       Impact factor: 1.205

7.  Exploratory experimentation and the role of histochemical techniques in the work of Jean Brachet, 1938-1952.

Authors:  R M Burian
Journal:  Hist Philos Life Sci       Date:  1997       Impact factor: 1.205

Review 8.  Modular Brain Networks.

Authors:  Olaf Sporns; Richard F Betzel
Journal:  Annu Rev Psychol       Date:  2015-09-21       Impact factor: 24.137

Review 9.  Network science of biological systems at different scales: A review.

Authors:  Marko Gosak; Rene Markovič; Jurij Dolenšek; Marjan Slak Rupnik; Marko Marhl; Andraž Stožer; Matjaž Perc
Journal:  Phys Life Rev       Date:  2017-11-03       Impact factor: 11.025

10.  Modularity: genes, development and evolution.

Authors:  Diogo Melo; Arthur Porto; James M Cheverud; Gabriel Marroig
Journal:  Annu Rev Ecol Evol Syst       Date:  2016-09-07       Impact factor: 13.915

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  7 in total

1.  Shifting levels of ecological network's analysis reveals different system properties.

Authors:  Nathalie Niquil; Matilda Haraldsson; Télesphore Sime-Ngando; Philippe Huneman; Stuart R Borrett
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2020-02-24       Impact factor: 6.237

2.  Hierarchy and levels: analysing networks to study mechanisms in molecular biology.

Authors:  William Bechtel
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2020-02-24       Impact factor: 6.237

3.  Unifying the essential concepts of biological networks: biological insights and philosophical foundations.

Authors:  Daniel Kostić; Claus C Hilgetag; Marc Tittgemeyer
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2020-02-24       Impact factor: 6.237

4.  The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets.

Authors:  Damian Szklarczyk; Annika L Gable; Katerina C Nastou; David Lyon; Rebecca Kirsch; Sampo Pyysalo; Nadezhda T Doncheva; Marc Legeay; Tao Fang; Peer Bork; Lars J Jensen; Christian von Mering
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6.  Modularity of the Human Musculoskeletal System: The Correlation between Functional Structures by Computer Tools Analysis.

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Journal:  Life (Basel)       Date:  2022-08-03

Review 7.  Using network models in person-centered care in psychiatry: How perspectivism could help to draw boundaries.

Authors:  Nina S de Boer; Daniel Kostić; Marcos Ross; Leon de Bruin; Gerrit Glas
Journal:  Front Psychiatry       Date:  2022-09-16       Impact factor: 5.435

  7 in total

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