Literature DB >> 32088735

PATHBIO: an international training program for precision mouse phenotyping.

Jesus Ruberte1, Paul N Schofield2,3, Cord Brakebusch4, Peter Vogel5, Yann Herault6, Guillem Gracia7, Colin McKerlie8, Martin Hrabĕ de Angelis9, Michael Hagn9, John P Sundberg3.   

Abstract

Design and production of genetically engineered mouse strains by individual research laboratories, research teams, large-scale consortia, and the biopharmaceutical industry have magnified the need for qualified personnel to identify, annotate, and validate (phenotype) these potentially new mouse models of human disease. The PATHBIO project has been recently established and funded by the European Union's ERASMUS+ Knowledge Alliance program to address the current shortfall in formally trained personnel. A series of teaching workshops will be given by experts on anatomy, histology, embryology, imaging, and comparative pathology to increase the availability of individuals with formal training to contribute to this important niche of Europe's biomedical research enterprise. These didactic and hands-on workshops are organized into three modules: (1) embryology, anatomy, histology, and the anatomical basis of imaging, (2) image-based phenotyping, and (3) pathology. The workshops are open to all levels of participants from recent graduates to Ph.D., M.D., and veterinary scientists. Participation is available on a competitive basis at no cost for attending. The first series of Workshop Modules was held in 2019 and these will continue for the next 2 years.

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Year:  2020        PMID: 32088735     DOI: 10.1007/s00335-020-09829-1

Source DB:  PubMed          Journal:  Mamm Genome        ISSN: 0938-8990            Impact factor:   2.957


  12 in total

1.  Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen.

Authors:  J P Sundberg; B A Sundberg; W G Beamer
Journal:  Mol Carcinog       Date:  1997-09       Impact factor: 4.784

2.  Pathbase and the MPATH ontology. Community resources for mouse histopathology.

Authors:  P N Schofield; M Gruenberger; J P Sundberg
Journal:  Vet Pathol       Date:  2010-06-29       Impact factor: 2.221

3.  The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer.

Authors:  Debra M Krupke; Dale A Begley; John P Sundberg; Joel E Richardson; Steven B Neuhauser; Carol J Bult
Journal:  Cancer Res       Date:  2017-11-01       Impact factor: 12.701

4.  Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research.

Authors:  Janan T Eppig; Cynthia L Smith; Judith A Blake; Martin Ringwald; James A Kadin; Joel E Richardson; Carol J Bult
Journal:  Methods Mol Biol       Date:  2017

5.  Pathbase: a new reference resource and database for laboratory mouse pathology.

Authors:  Paul N Schofield; Jonathan B L Bard; Jacques Boniver; Vincenzo Covelli; Philippe Delvenne; Michele Ellender; Wilhelm Engstrom; Wolfgang Goessner; Michael Gruenberger; Heinz Hoefler; John W Hopewell; Mariateresa Mancuso; Carmel Mothersill; Leticia Quintanilla-Martinez; Bjorn Rozell; Hannu Sariola; John P Sundberg; Andrew Ward
Journal:  Radiat Prot Dosimetry       Date:  2004       Impact factor: 0.972

6.  Training mouse pathologists: 16th annual workshop on the pathology of mouse models of human disease.

Authors:  John P Sundberg; Kelli Boyd; Harm Hogenesch; Alexander Yu Nikitin; Piper M Treuting; Jerrold M Ward
Journal:  Lab Anim (NY)       Date:  2018-01-31       Impact factor: 12.625

7.  Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas.

Authors:  John P Sundberg; Timothy M Stearns; Joongho Joh; Mary Proctor; Arvind Ingle; Kathleen A Silva; Soheil S Dadras; A Bennett Jenson; Shin-je Ghim
Journal:  PLoS One       Date:  2014-12-04       Impact factor: 3.240

8.  Mouse Phenome Database: an integrative database and analysis suite for curated empirical phenotype data from laboratory mice.

Authors:  Molly A Bogue; Stephen C Grubb; David O Walton; Vivek M Philip; Georgi Kolishovski; Tim Stearns; Matthew H Dunn; Daniel A Skelly; Beena Kadakkuzha; Gregg TeHennepe; Govindarajan Kunde-Ramamoorthy; Elissa J Chesler
Journal:  Nucleic Acids Res       Date:  2018-01-04       Impact factor: 16.971

Review 9.  Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse.

Authors:  Janan T Eppig
Journal:  ILAR J       Date:  2017-07-01

Review 10.  Modeling human disease in rodents by CRISPR/Cas9 genome editing.

Authors:  Marie-Christine Birling; Yann Herault; Guillaume Pavlovic
Journal:  Mamm Genome       Date:  2017-07-04       Impact factor: 2.957

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  1 in total

1.  Hypoglossal Nerve Abnormalities as Biomarkers for Central Nervous System Defects in Mouse Lines Producing Embryonically Lethal Offspring.

Authors:  Lukas F Reissig; Atieh Seyedian Moghaddam; Fabrice Prin; Robert Wilson; Antonella Galli; Catherine Tudor; Jaqueline K White; Stefan H Geyer; Timothy J Mohun; Wolfgang J Weninger
Journal:  Front Neuroanat       Date:  2021-01-28       Impact factor: 3.856

  1 in total

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