Literature DB >> 15623888

Pathbase: a new reference resource and database for laboratory mouse pathology.

Paul N Schofield1, Jonathan B L Bard, Jacques Boniver, Vincenzo Covelli, Philippe Delvenne, Michele Ellender, Wilhelm Engstrom, Wolfgang Goessner, Michael Gruenberger, Heinz Hoefler, John W Hopewell, Mariateresa Mancuso, Carmel Mothersill, Leticia Quintanilla-Martinez, Bjorn Rozell, Hannu Sariola, John P Sundberg, Andrew Ward.   

Abstract

Pathbase (http://www.pathbase.net) is a web accessible database of histopathological images of laboratory mice, developed as a resource for the coding and archiving of data derived from the analysis of mutant or genetically engineered mice and their background strains. The metadata for the images, which allows retrieval and interoperability with other databases, is derived from a series of orthogonal ontologies and controlled vocabularies. One of these controlled vocabularies, MPATH, was developed by the Pathbase Consortium as a formal description of the content of mouse histopathological images. The database currently has over 1000 images on-line with 2000 more under curation and presents a paradigm for the development of future databases dedicated to aspects of experimental biology.

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Year:  2004        PMID: 15623888     DOI: 10.1093/rpd/nch101

Source DB:  PubMed          Journal:  Radiat Prot Dosimetry        ISSN: 0144-8420            Impact factor:   0.972


  11 in total

1.  Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening.

Authors:  John P Sundberg; Kathleen A Silva; Lloyd E King; C Herbert Pratt
Journal:  Methods Mol Biol       Date:  2016

2.  Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.

Authors:  Annerose Berndt; Clinton L Cario; Kathleen A Silva; Victoria E Kennedy; David E Harrison; Beverly Paigen; John P Sundberg
Journal:  Cancer Res       Date:  2011-07-15       Impact factor: 12.701

3.  Reproducibility of histopathological findings in experimental pathology of the mouse: a sorry tail.

Authors:  Jerrold M Ward; Paul N Schofield; John P Sundberg
Journal:  Lab Anim (NY)       Date:  2017-03-22       Impact factor: 12.625

4.  Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training.

Authors:  John P Sundberg; Beth A Sundberg; Paul Schofield
Journal:  Mamm Genome       Date:  2008-09-17       Impact factor: 2.957

5.  Approaches to Investigating Complex Genetic Traits in a Large-Scale Inbred Mouse Aging Study.

Authors:  J P Sundberg; A Berndt; B A Sundberg; K A Silva; V Kennedy; R S Smith; T K Cooper; P N Schofield
Journal:  Vet Pathol       Date:  2016-03       Impact factor: 2.221

6.  PATHBIO: an international training program for precision mouse phenotyping.

Authors:  Jesus Ruberte; Paul N Schofield; Cord Brakebusch; Peter Vogel; Yann Herault; Guillem Gracia; Colin McKerlie; Martin Hrabĕ de Angelis; Michael Hagn; John P Sundberg
Journal:  Mamm Genome       Date:  2020-02-22       Impact factor: 2.957

7.  Genetic determinants of fibro-osseous lesions in aged inbred mice.

Authors:  Annerose Berndt; Cheryl Ackert-Bicknell; Kathleen A Silva; Victoria E Kennedy; Beth A Sundberg; Justin M Cates; Paul N Schofield; John P Sundberg
Journal:  Exp Mol Pathol       Date:  2015-11-14       Impact factor: 3.362

8.  Improving disease gene prioritization by comparing the semantic similarity of phenotypes in mice with those of human diseases.

Authors:  Anika Oellrich; Robert Hoehndorf; Georgios V Gkoutos; Dietrich Rebholz-Schuhmann
Journal:  PLoS One       Date:  2012-06-14       Impact factor: 3.240

9.  The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice.

Authors:  John P Sundberg; Annerose Berndt; Beth A Sundberg; Kathleen A Silva; Victoria Kennedy; Roderick Bronson; Rong Yuan; Beverly Paigen; David Harrison; Paul N Schofield
Journal:  Pathobiol Aging Age Relat Dis       Date:  2011-06-01

10.  Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.

Authors:  Steve D M Brown; John M Hancock; Hilary Gates
Journal:  PLoS Genet       Date:  2006-08-25       Impact factor: 5.917

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