Josefine Freyberg1, Søren Brage2, Lars Vedel Kessing1, Maria Faurholt-Jepsen3. 1. The Copenhagen Affective Disorder research Center (CADIC), Psychiatric Center Copenhagen, Rigshospitalet, and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. 2. MRC Epidemiology Unit, Cambridge, United Kingdom. 3. The Copenhagen Affective Disorder research Center (CADIC), Psychiatric Center Copenhagen, Rigshospitalet, and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: maria.faurholtjepsen@regionh.dk.
Abstract
BACKGROUND: Heart rate variability (HRV) and psychomotor activity have been found reduced in bipolar disorder (BD) but has never been investigated in newly diagnosed BD and unaffected relatives. The present study aimed to compare HRV and psychomotor activity between newly diagnosed patients with BD, their unaffected first-degree relatives (UR), and healthy control individuals (HC). METHODS: 20 newly diagnosed patients with BD, 20 of their UR, and 20 age- and sex-matched HC were included. Measurements of HRV for five minutes and heart rate and acceleration for seven days were conducted. Activity energy expenditure (AEE) was derived from the latter. Linear mixed effect regression models were conducted to compare the three groups. RESULTS: HRV did not differ in any measure between the three groups of participants. Similarly, AEE (kJ/day/kg) did not differ between the three groups in neither daily means (BD: 63.6, UR: 64.1, HC: 62.1) nor when divided into quarter-daily intervals. LIMITATIONS: The relatively small size of the study may affect the validity of the results. CONCLUSION: Patients with newly diagnosed BD and UR do not present with decreased HRV or AEE. These results contrast prior findings from BD patients with more advanced stages of the disorder, suggesting that these outcomes progress with illness duration.
BACKGROUND: Heart rate variability (HRV) and psychomotor activity have been found reduced in bipolar disorder (BD) but has never been investigated in newly diagnosed BD and unaffected relatives. The present study aimed to compare HRV and psychomotor activity between newly diagnosed patients with BD, their unaffected first-degree relatives (UR), and healthy control individuals (HC). METHODS: 20 newly diagnosed patients with BD, 20 of their UR, and 20 age- and sex-matched HC were included. Measurements of HRV for five minutes and heart rate and acceleration for seven days were conducted. Activity energy expenditure (AEE) was derived from the latter. Linear mixed effect regression models were conducted to compare the three groups. RESULTS: HRV did not differ in any measure between the three groups of participants. Similarly, AEE (kJ/day/kg) did not differ between the three groups in neither daily means (BD: 63.6, UR: 64.1, HC: 62.1) nor when divided into quarter-daily intervals. LIMITATIONS: The relatively small size of the study may affect the validity of the results. CONCLUSION:Patients with newly diagnosed BD and UR do not present with decreased HRV or AEE. These results contrast prior findings from BDpatients with more advanced stages of the disorder, suggesting that these outcomes progress with illness duration.
Authors: Joseph F Goldberg; Roy H Perlis; Charles L Bowden; Michael E Thase; David J Miklowitz; Lauren B Marangell; Joseph R Calabrese; Andrew A Nierenberg; Gary S Sachs Journal: Am J Psychiatry Date: 2009-01-02 Impact factor: 18.112
Authors: Lars Vedel Kessing; Klaus Munkholm; Maria Faurholt-Jepsen; Kamilla Woznica Miskowiak; Lars Bo Nielsen; Ruth Frikke-Schmidt; Claus Ekstrøm; Ole Winther; Bente Klarlund Pedersen; Henrik Enghusen Poulsen; Roger S McIntyre; Flavio Kapczinski; Wagner F Gattaz; Jakob Bardram; Mads Frost; Oscar Mayora; Gitte Moos Knudsen; Mary Phillips; Maj Vinberg Journal: BMJ Open Date: 2017-06-23 Impact factor: 2.692
Authors: Søren Brage; Ulf Ekelund; Niels Brage; Mark A Hennings; Karsten Froberg; Paul W Franks; Nicholas J Wareham Journal: J Appl Physiol (1985) Date: 2007-04-26
Authors: Michael Berger; Florian Seemüller; Alessandra Voggt; Michael Obermeier; Franca Kirchberg; Anja Löw; Michael Riedel; Clemens von Schacky; Emanuel Severus Journal: Int J Bipolar Disord Date: 2022-04-01