BACKGROUND: Power spectral analysis of heart rate variability (HRV) has recently been shown to be a reliable non-invasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function. METHODS: We studied 39 euthymic bipolar patients and 39 controls, matched for age and sex. A high-resolution electrocardiogram was obtained during complete rest. Spectral analysis of R-R intervals was performed by the fast Fourier transform algorithm. RESULTS: Euthymic bipolar patients at rest are characterized by markedly low HRV, independent of specific drug treatments. CONCLUSION: While these results of autonomic stability in euthymic bipolar patients are counter-intuitive, the findings may be important in understanding pathophysiology of bipolar affective illness.
BACKGROUND: Power spectral analysis of heart rate variability (HRV) has recently been shown to be a reliable non-invasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function. METHODS: We studied 39 euthymic bipolarpatients and 39 controls, matched for age and sex. A high-resolution electrocardiogram was obtained during complete rest. Spectral analysis of R-R intervals was performed by the fast Fourier transform algorithm. RESULTS: Euthymic bipolarpatients at rest are characterized by markedly low HRV, independent of specific drug treatments. CONCLUSION: While these results of autonomic stability in euthymic bipolarpatients are counter-intuitive, the findings may be important in understanding pathophysiology of bipolar affective illness.
Authors: M L Prieto; A B Cuéllar-Barboza; W V Bobo; V L Roger; F Bellivier; M Leboyer; C P West; M A Frye Journal: Acta Psychiatr Scand Date: 2014-05-22 Impact factor: 6.392
Authors: Katrina C Johnson; Patricia A Brennan; Zachary N Stowe; Ellen Leibenluft; D Jeffrey Newport Journal: J Child Psychol Psychiatry Date: 2013-08-28 Impact factor: 8.982
Authors: Miguel L Prieto; Louis A Schenck; Jennifer L Kruse; James P Klaas; Alanna M Chamberlain; William V Bobo; Frank Bellivier; Marion Leboyer; Véronique L Roger; Robert D Brown; Walter A Rocca; Mark A Frye Journal: J Affect Disord Date: 2016-01-13 Impact factor: 4.839