Atsuya Miki1, Miho Kumoi2, Naoyuki Maeda3,4, Shizuka Koh3,5, Kenji Matsushita3, Kohji Nishida3,6. 1. Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan. amiki@ophthal.med.osaka-u.ac.jp. 2. Department of Ophthalmology, National Hospital Organization Osaka National Hospital, Osaka, Japan. 3. Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan. 4. Kozaki Eye Clinic, Osaka, Japan. 5. Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan. 6. Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan.
Abstract
PURPOSE: To evaluate changes in refractive error and corneal tomographic measurements after 24-h monitoring of intraocular pressure patterns with a contact lens sensor (CLS). STUDY DESIGN: Prospective, longitudinal, observational study. PATIENTS AND METHODS: Fourteen eyes of 14 consecutive patients who underwent 24-h CLS monitoring were enrolled. The objective spherical equivalent (SE) refractive error was measured using automated refraction and keratometry. The axial power, instantaneous power, and corneal thickness at the central, paracentral, midperipheral, and peripheral cornea were measured with swept-source anterior-segment optical coherence tomography. Measurements were performed at baseline, immediately after monitoring, and at follow-up visits 2-4 days after monitoring. RESULTS: The myopic SE increased significantly (P < 0.001) from - 5.1 ± 4.2 to - 6.0 ± 4.0, D after 24-h monitoring with a CLS and returned to the premonitoring level at the second visit (- 5.3 ± 4.4 D, P = 0.315). Decreases in the midperipheral and peripheral axial powers and the paracentral instantaneous power and increases in the central instantaneous power and peripheral corneal thickness occurred after CLS monitoring. CONCLUSION: Twenty-four-hour monitoring with a CLS resulted in significant increases in the myopic refractive error and corneal central steepening and midperipheral flattening. Although these changes are transient and do not negate the clinical merits of the CLS, clinicians should be aware of these potential adverse events. Three-dimensional evaluation of corneal deformation with anterior segment optical coherence tomography is a powerful tool for assessing and improving the safety, tolerability, and accuracy of CLS devices.
PURPOSE: To evaluate changes in refractive error and corneal tomographic measurements after 24-h monitoring of intraocular pressure patterns with a contact lens sensor (CLS). STUDY DESIGN: Prospective, longitudinal, observational study. PATIENTS AND METHODS: Fourteen eyes of 14 consecutive patients who underwent 24-h CLS monitoring were enrolled. The objective spherical equivalent (SE) refractive error was measured using automated refraction and keratometry. The axial power, instantaneous power, and corneal thickness at the central, paracentral, midperipheral, and peripheral cornea were measured with swept-source anterior-segment optical coherence tomography. Measurements were performed at baseline, immediately after monitoring, and at follow-up visits 2-4 days after monitoring. RESULTS: The myopic SE increased significantly (P < 0.001) from - 5.1 ± 4.2 to - 6.0 ± 4.0, D after 24-h monitoring with a CLS and returned to the premonitoring level at the second visit (- 5.3 ± 4.4 D, P = 0.315). Decreases in the midperipheral and peripheral axial powers and the paracentral instantaneous power and increases in the central instantaneous power and peripheral corneal thickness occurred after CLS monitoring. CONCLUSION: Twenty-four-hour monitoring with a CLS resulted in significant increases in the myopic refractive error and corneal central steepening and midperipheral flattening. Although these changes are transient and do not negate the clinical merits of the CLS, clinicians should be aware of these potential adverse events. Three-dimensional evaluation of corneal deformation with anterior segment optical coherence tomography is a powerful tool for assessing and improving the safety, tolerability, and accuracy of CLS devices.
Authors: J H Liu; D F Kripke; R E Hoffman; M D Twa; R T Loving; K M Rex; N Gupta; R N Weinreb Journal: Invest Ophthalmol Vis Sci Date: 1998-12 Impact factor: 4.799
Authors: Kouros Nouri-Mahdavi; Douglas Hoffman; Anne L Coleman; Gang Liu; Gang Li; Douglas Gaasterland; Joseph Caprioli Journal: Ophthalmology Date: 2004-09 Impact factor: 12.079